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Molecules 2009, 14(10), 3881-3905; doi:10.3390/molecules14103881

Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers

Institute of Organic Chemistry PAS, Kasprzaka Str. 44/52 01-224 Warsaw, Poland
National Institute of Public Health – PZH, Chocimska Str. 24, 00-791 Warsaw, Poland
Author to whom correspondence should be addressed.
Received: 31 August 2009 / Revised: 22 September 2009 / Accepted: 27 September 2009 / Published: 29 September 2009
(This article belongs to the Special Issue Dendrimers - from Synthesis to Applications)
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Novel polyfunctional small amphiphilic peptide dendrimers characterized by incorporation of a new core compounds – tris-amino acids or tetrakis-amino alcohols that originated from a series of basic amino acids – were efficiently synthesized. These new core elements yielded molecules with multiple branching and (+5)/(+6) charge at the 1-st dendrimer generation. Dendrimers exhibited significant antimicrobial potency against Gram(+) and Gram(-) strains involving also multiresistant reference strains (S. aureus ATCC 43300 and E. coli ATCC BAA-198). In addition, high activity against fungi from the Candida genus was detected. More charged and more hydrophobic peptide dendrimers expressed hemolytic properties.
Keywords: dendrimeric peptides; antimicrobial; antibiotic resistance dendrimeric peptides; antimicrobial; antibiotic resistance
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Polcyn, P.; Jurczak, M.; Rajnisz, A.; Solecka, J.; Urbanczyk-Lipkowska, Z. Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers. Molecules 2009, 14, 3881-3905.

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