Molecules 2009, 14(10), 3881-3905; doi:10.3390/molecules14103881
Article

Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers

Piotr Polcyn 1 email, Margarita Jurczak 1 email, Aleksandra Rajnisz 2 email, Jolanta Solecka 2 email and Zofia Urbanczyk-Lipkowska 1,* email
1 Institute of Organic Chemistry PAS, Kasprzaka Str. 44/52 01-224 Warsaw, Poland 2 National Institute of Public Health – PZH, Chocimska Str. 24, 00-791 Warsaw, Poland
* Author to whom correspondence should be addressed.
Received: 31 August 2009; in revised form: 22 September 2009 / Accepted: 27 September 2009 / Published: 29 September 2009
(This article belongs to the Special Issue Dendrimers - from Synthesis to Applications)
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Abstract: Novel polyfunctional small amphiphilic peptide dendrimers characterized by incorporation of a new core compounds – tris-amino acids or tetrakis-amino alcohols that originated from a series of basic amino acids – were efficiently synthesized. These new core elements yielded molecules with multiple branching and (+5)/(+6) charge at the 1-st dendrimer generation. Dendrimers exhibited significant antimicrobial potency against Gram(+) and Gram(-) strains involving also multiresistant reference strains (S. aureus ATCC 43300 and E. coli ATCC BAA-198). In addition, high activity against fungi from the Candida genus was detected. More charged and more hydrophobic peptide dendrimers expressed hemolytic properties.
Keywords: dendrimeric peptides; antimicrobial; antibiotic resistance

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MDPI and ACS Style

Polcyn, P.; Jurczak, M.; Rajnisz, A.; Solecka, J.; Urbanczyk-Lipkowska, Z. Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers. Molecules 2009, 14, 3881-3905.

AMA Style

Polcyn P, Jurczak M, Rajnisz A, Solecka J, Urbanczyk-Lipkowska Z. Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers. Molecules. 2009; 14(10):3881-3905.

Chicago/Turabian Style

Polcyn, Piotr; Jurczak, Margarita; Rajnisz, Aleksandra; Solecka, Jolanta; Urbanczyk-Lipkowska, Zofia. 2009. "Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers." Molecules 14, no. 10: 3881-3905.

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