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Molecules 2009, 14(10), 3881-3905; doi:10.3390/molecules14103881
Article

Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers

1
, 1
, 2
, 2
 and 1,*
Received: 31 August 2009; in revised form: 22 September 2009 / Accepted: 27 September 2009 / Published: 29 September 2009
(This article belongs to the Special Issue Dendrimers - from Synthesis to Applications)
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Abstract: Novel polyfunctional small amphiphilic peptide dendrimers characterized by incorporation of a new core compounds – tris-amino acids or tetrakis-amino alcohols that originated from a series of basic amino acids – were efficiently synthesized. These new core elements yielded molecules with multiple branching and (+5)/(+6) charge at the 1-st dendrimer generation. Dendrimers exhibited significant antimicrobial potency against Gram(+) and Gram(-) strains involving also multiresistant reference strains (S. aureus ATCC 43300 and E. coli ATCC BAA-198). In addition, high activity against fungi from the Candida genus was detected. More charged and more hydrophobic peptide dendrimers expressed hemolytic properties.
Keywords: dendrimeric peptides; antimicrobial; antibiotic resistance dendrimeric peptides; antimicrobial; antibiotic resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Polcyn, P.; Jurczak, M.; Rajnisz, A.; Solecka, J.; Urbanczyk-Lipkowska, Z. Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers. Molecules 2009, 14, 3881-3905.

AMA Style

Polcyn P, Jurczak M, Rajnisz A, Solecka J, Urbanczyk-Lipkowska Z. Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers. Molecules. 2009; 14(10):3881-3905.

Chicago/Turabian Style

Polcyn, Piotr; Jurczak, Margarita; Rajnisz, Aleksandra; Solecka, Jolanta; Urbanczyk-Lipkowska, Zofia. 2009. "Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers." Molecules 14, no. 10: 3881-3905.



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