Special Issue "Cross-Coupling Reactions in Organic Synthesis"

Guest Editor
Dr. Laurent Djakovitch
Universität de Lyon, CNRS, UMR 5256, IRCELYON, Institut de recherches sur la catalyse et l'environnement de Lyon, 2 avenue Albert Einstein, F-69626 Villeurbanne, France
E-Mail:
Interests: homogeneous and heterogeneous palladium catalysis; cross-coupling reactions; direct cross-coupling; oxidative cross-coupling; C-H activation; multi-tasks heterogeneous catalysts; one-pot synthesis of bioactive molecules; biomass upgrading

Dear Colleagues

Cross-coupling reactions are key steps in the synthesis of a number of bioactive molecules of interest in pharmaceuticals, agrochemicals, cosmetics and more generally in fine chemicals. These reactions, including substitution of an aryl, vinyl or aklyl halide by nucleophile under transition metal catalysed procedures, have been the focus of many academic and industrial research groups leading to significant improvements during the last two decades. This special issue of Molecules dedicated to Cross-coupling Reactions calls for both fundamental and applied contributions in this field that remain a hot topic for both academics and industrials. Special attention will be paid to original contributions and feature articles reporting new or improved cross-coupling methodologies. Review papers are strongly encouraged, with special interests to those focusing on mechanistic aspects.

Dr. Laurent Djakovitch
Guest Editor

Submission

• cross-coupling reactions
• palladium catalysis
• nickel catalysis
• copper Catalysis
• Heck-Mizoroki reaction
• Sonogashira reaction
• Suzuki-Miyaura reaction
• Stille reaction
• Corriu-Kumada reaction
• Buchwald-Hartwig reaction
• Negishi reaction
• direct cross-coupling
• oxidative cross-coupling
• C-H activation
• homogeneous and heterogeneous catalysis
• multi-tasks catalysts
• one-pot synthesis of bioactive molecules through cross-coupling reactions

Manuscript ID: Molecules-croscoup-20091127-Djakovitch-fr
Type of Paper: Review
Title: Recent Advances in the Synthesis of Heteroaromatics via Heterogeneously Catalysed Cross-coupling Reactions.
Authors: Nelly Batail, Marie Genelot, Lionel Joucla and Laurent Djakovitch
Affiliation: Université de Lyon, CNRS, UMR 5256, IRCELYON, Institut de recherches sur la catalyse et l’environnement de Lyon, 2 avenue Albert Einstein, F-69626 Villeurbanne, France; E-Mail: Laurent.Djakovitch@ircelyon.univ-lyon1.fr
Abstract: Heteroaromatics are important substructures found in numerous natural or synthetic alkaloids. The diversity of the structures encountered, as well as their biological and pharmaceutical relevance, have motivated research aimed at the development of new economical, efficient and selective synthetic strategies. Over more than 100 years research, this hot topic resulted in numerous so-called "classical synthetic methods" that have really contributed to this important area. However, when the selective synthesis of highly functional heteroaromatics like indoles, quinolones, coumarines… is considered these methods remain limited. Recently transition metal-catalysed procedures for the synthesis of such compounds, and further transformations, have been developed providing increased tolerance toward functional groups and leading generally to higher reaction yields. Many of these methods have proven to be most powerful and are currently applied in target- or diversity-oriented syntheses.
This review article aim at reporting the recent developments devoted to this important area, focusing on the use of heterogeneous catalysed procedures that include either the heteroannulation towards the nuclei or their transformations to highly substituted compounds.