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Molecules 2010, 15(12), 9157-9173; doi:10.3390/molecules15129157
Article

Sonogashira Reaction of Aryl and Heteroaryl Halides with Terminal Alkynes Catalyzed by a Highly Efficient and Recyclable Nanosized MCM-41 Anchored Palladium Bipyridyl Complex

1, 1, 1, 2 and 1,*
Received: 11 November 2010 / Revised: 6 December 2010 / Accepted: 9 December 2010 / Published: 10 December 2010
(This article belongs to the Special Issue Cross-Coupling Reactions in Organic Synthesis)
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Abstract

A heterogeneous catalyst, nanosized MCM-41-Pd, was used to catalyze the Sonogashira coupling of aryl and heteroaryl halides with terminal alkynes in the presence of CuI and triphenylphosphine. The coupling products were obtained in high yields using low Pd loadings to 0.01 mol%, and the nanosized MCM-41-Pd catalyst was recovered by centrifugation of the reaction solution and re-used in further runs without significant loss of reactivity.
Keywords: Sonogashira reaction; mesoporous silica; palladium complex; recyclable catalyst; heterogeneous catalysis Sonogashira reaction; mesoporous silica; palladium complex; recyclable catalyst; heterogeneous catalysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lin, B.-N.; Huang, S.-H.; Wu, W.-Y.; Mou, C.-Y.; Tsai, F.-Y. Sonogashira Reaction of Aryl and Heteroaryl Halides with Terminal Alkynes Catalyzed by a Highly Efficient and Recyclable Nanosized MCM-41 Anchored Palladium Bipyridyl Complex. Molecules 2010, 15, 9157-9173.

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