Molecules 2011, 16(2), 1129-1165; doi:10.3390/molecules16021129
Review

Cross-Coupling Reactions as Valuable Tool for the Preparation of PET Radiotracers

1, 2 and 1,* email
Received: 30 November 2010; in revised form: 17 January 2011 / Accepted: 21 January 2011 / Published: 26 January 2011
(This article belongs to the Special Issue Cross-Coupling Reactions in Organic Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The increasing application of positron emission tomography (PET) in nuclear medicine has stimulated the extensive development of a multitude of new radiotracers and novel radiolabeling procedures with the most prominent short-lived positron emitters carbon-11 and fluorine-18. Radiolabeling with these radionuclides represents a remarkable challenge. Special attention has to be paid to synthesis time and specific labeling techniques due to the short physical half life of the respective radionuclides 11C (t1/2 = 20.4 min) and 18F (t1/2 = 109.8 min). In the past, numerous transition metal-catalyzed reactions were employed in organic chemistry, even though only a handful of these coupling reactions were adopted in radiochemical practice. Thus, the implementation of modern synthesis methods like cross-coupling reactions offers the possibility to develop a wide variety of novel radiotracers. The introduction of catalysts based on transition metal complexes bears a high potential for rapid, efficient, highly selective and functional group-tolerating incorporation of carbon-11 and fluorine-18 into target molecules. This review deals with design, application and improvement of transition metal-mediated carbon-carbon as well as carbon-heteroatom cross-coupling reactions as a labeling feature with the focus on the preparation of radiolabeled compounds for molecular imaging.
Keywords: cross-coupling; radiolabeling; carbon-11; fluorine-18
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MDPI and ACS Style

Pretze, M.; Große-Gehling, P.; Mamat, C. Cross-Coupling Reactions as Valuable Tool for the Preparation of PET Radiotracers. Molecules 2011, 16, 1129-1165.

AMA Style

Pretze M, Große-Gehling P, Mamat C. Cross-Coupling Reactions as Valuable Tool for the Preparation of PET Radiotracers. Molecules. 2011; 16(2):1129-1165.

Chicago/Turabian Style

Pretze, Marc; Große-Gehling, Philipp; Mamat, Constantin. 2011. "Cross-Coupling Reactions as Valuable Tool for the Preparation of PET Radiotracers." Molecules 16, no. 2: 1129-1165.

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