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Molecules 2012, 17(3), 3560-3573; doi:10.3390/molecules17033560
Article

Synthesis of a New Group of Aliphatic Hydrazide Derivatives and the Correlations between Their Molecular Structure and Biological Activity

Department of Chemistry, University of Life Sciences in Lublin, ul. Akademicka 15, 20-950 Lublin, Poland
Received: 25 January 2012 / Revised: 24 February 2012 / Accepted: 14 March 2012 / Published: 22 March 2012
(This article belongs to the Special Issue Advances in Medicinal Chemistry of Antifungals)
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Abstract

In view of the growing demand for new compounds showing biological activity against pathogenic microorganisms, such as pathogenic and phytopathogenic fungi, the objective of this study was to synthesize a new group of aliphatic and aromatic derivatives of hydrazide. In consequence of the reactions observed during synthesis, the resulting compounds retained their linear structure. Their structure and lipophilicity, measured by high-performance liquid chromatography (HPLC), were analyzed. Correlations were determined between the compounds’ molecular parameters and biological activity against Fusarium solani and Fusarium oxysporum fungi. The investigated compounds were also examined for their antifungal activity against Aspergillus fumigatus. The obtained results indicate that compounds with fluorine-containing substituents penetrate the cell structure more effectively and are characterized by higher antifungal potential than analogues with different substituents.
Keywords: : hydrazides; Fusarium solani; Fusarium oxysporum; antifungal activity; synthesis : hydrazides; Fusarium solani; Fusarium oxysporum; antifungal activity; synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kostecka, M. Synthesis of a New Group of Aliphatic Hydrazide Derivatives and the Correlations between Their Molecular Structure and Biological Activity. Molecules 2012, 17, 3560-3573.

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