Synthesis of a New Group of Aliphatic Hydrazide Derivatives and the Correlations between Their Molecular Structure and Biological Activity

doi:10.3390/molecules17033560

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Molecules 2012, 17(3), 3560-3573; doi:10.3390/molecules17033560

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Synthesis of a New Group of Aliphatic Hydrazide Derivatives and the Correlations between Their Molecular Structure and Biological Activity

Małgorzata Kostecka

Department of Chemistry, University of Life Sciences in Lublin, ul. Akademicka 15, 20-950 Lublin, Poland

Received: 25 January 2012; in revised form: 24 February 2012 / Accepted: 14 March 2012 / Published: 22 March 2012

(This article belongs to the Special Issue Advances in Medicinal Chemistry of Antifungals)

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Abstract: In view of the growing demand for new compounds showing biological activity against pathogenic microorganisms, such as pathogenic and phytopathogenic fungi, the objective of this study was to synthesize a new group of aliphatic and aromatic derivatives of hydrazide. In consequence of the reactions observed during synthesis, the resulting compounds retained their linear structure. Their structure and lipophilicity, measured by high-performance liquid chromatography (HPLC), were analyzed. Correlations were determined between the compounds’ molecular parameters and biological activity against Fusarium solani and Fusarium oxysporum fungi. The investigated compounds were also examined for their antifungal activity against Aspergillus fumigatus. The obtained results indicate that compounds with fluorine-containing substituents penetrate the cell structure more effectively and are characterized by higher antifungal potential than analogues with different substituents.

Keywords: : hydrazides; Fusarium solani; Fusarium oxysporum; antifungal activity; synthesis

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MDPI and ACS Style

Kostecka, M. Synthesis of a New Group of Aliphatic Hydrazide Derivatives and the Correlations between Their Molecular Structure and Biological Activity. Molecules 2012, 17, 3560-3573.

AMA Style

Kostecka M. Synthesis of a New Group of Aliphatic Hydrazide Derivatives and the Correlations between Their Molecular Structure and Biological Activity. Molecules. 2012; 17(3):3560-3573.

Chicago/Turabian Style

Kostecka, Małgorzata. 2012. "Synthesis of a New Group of Aliphatic Hydrazide Derivatives and the Correlations between Their Molecular Structure and Biological Activity." Molecules 17, no. 3: 3560-3573.

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