Special Issue "Calixarenes and Resorcinarenes"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (28 February 2013)
Dr. Jordan L. Fantini (Website)
Department of Chemistry & Biochemistry, Denison University, Granville, OH 43023, USA
Interests: calixarenes chemistry; methylene-bridge-substituted calixarenes; azide-terminated calixarenes; di- and tricalixarenes
Calixarenes and resorcinarenes are families of macrocyclic species that have become a broad field of chemical research over the past few decades. This area flourishes and is vibrant today as these molecules are studied in areas such as catalysis, molecular recognition, sensing, and devices. At the forefront, researchers around the world are developing yet more elaborate molecular and supramolecular chemistry of these versatile molecules and expanding their application into previously unexplored fields. With this special issue of Molecules, we seek previously unpublished manuscripts on the chemistry of calixarenes and resorcinarenes, including their synthesis, structure, properties, and applications.
Dr. Jordan L. Fantini,
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- host-guest systems
- molecular devices
- molecular recognition
- pi interactions
- Supramolecular chemistry
- water-soluble receptors
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of the Paper: Review
Title: Calix[n]arenes as Goldmines for the Development of Chemical Entities of Pharmacological Interest
Authors: Eduardo Vinícius Varejão 1, Sergio Antonio Fernandes 1,* and Ângelo de Fátima 2,*
Affiliations: 1 Grupo de Química Supramolecular e Biomimética (GQSB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, MG, 36570-000, Brazil
2 Grupo de Estudos em Química Orgânica e Biológica (GEQOB), Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil
Abstract: Calix[n]arenes are macrocyclic cone-shaped compounds formed by phenolic units linked by methylene groups in ortho position. The structural features make calix[n]arenes a versatile class of molecules of great interest particularly in the pharmaceutical field. The cavity-like shape gives calix[n]arenes the ability to selectively encapsulate ions or neutral molecules, which generates carriers systems capable of increasing the solubility and diffusivity of chemical species. The resulting systems can additionally function as delivers of bioactive guest molecules. This review aims to discuss the biological properties of a variety of calix[n]arenes, focusing their capacity of working as host molecules for improving drug potency, action and/or delivery. The most used spectrometric and spectroscopic methods used to study calix[n]arene inclusion complexes and their effects on solubility, diffusivity and potency of bioactive molecules will be also detailed.