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Special Issue "Calixarenes and Resorcinarenes"

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A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (28 February 2013)

Special Issue Editor

Guest Editor
Dr. Jordan L. Fantini

Department of Chemistry & Biochemistry, Denison University, Granville, OH 43023, USA
Website | E-Mail
Interests: calixarenes chemistry; methylene-bridge-substituted calixarenes; azide-terminated calixarenes; di- and tricalixarenes

Special Issue Information

Dear Colleagues,

Calixarenes and resorcinarenes are families of macrocyclic species that have become a broad field of chemical research over the past few decades. This area flourishes and is vibrant today as these molecules are studied in areas such as catalysis, molecular recognition, sensing, and devices. At the forefront, researchers around the world are developing yet more elaborate molecular and supramolecular chemistry of these versatile molecules and expanding their application into previously unexplored fields. With this special issue of Molecules, we seek previously unpublished manuscripts on the chemistry of calixarenes and resorcinarenes, including their synthesis, structure, properties, and applications.

Dr. Jordan L. Fantini,
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).

Keywords

  • aggregation
  • calixarenes
  • host-guest systems
  • molecular devices
  • molecular recognition
  • multivalency
  • nanostructures
  • pi interactions
  • receptors
  • resorcinarenes
  • self-assembly
  • Supramolecular chemistry
  • thiacalixarenes
  • water-soluble receptors

Published Papers (2 papers)

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Research

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Open AccessArticle Anionic Calixarene-Capped Silver Nanoparticles Show Species-Dependent Binding to Serum Albumins
Molecules 2013, 18(5), 5993-6007; doi:10.3390/molecules18055993
Received: 28 February 2013 / Revised: 25 April 2013 / Accepted: 9 May 2013 / Published: 21 May 2013
Cited by 3 | PDF Full-text (752 KB) | HTML Full-text | XML Full-text
Abstract
The anionic calixarenes para-sulphonatocalix[4]arene and 1,3-di-Ophosphonatocalix[ 4]arene, have been used to cap silver nanoparticles. The binding of these functional particles with regard to various serum albumins (bovine serum albumin, human serum albumin, porcine serum albumin and sheep serum albumin) has been studied by
[...] Read more.
The anionic calixarenes para-sulphonatocalix[4]arene and 1,3-di-Ophosphonatocalix[ 4]arene, have been used to cap silver nanoparticles. The binding of these functional particles with regard to various serum albumins (bovine serum albumin, human serum albumin, porcine serum albumin and sheep serum albumin) has been studied by variable temperature fluorescence spectroscopy. The quenching of the fluorescence of the proteins was shown to vary as a function of the anionic calixarene capping molecule and also as a function of the origin of the serum albumin. It is thus possible to discriminate between the different species. Full article
(This article belongs to the Special Issue Calixarenes and Resorcinarenes)
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Review

Jump to: Research

Open AccessReview The Third Dimension of Reading the Sugar Code by Lectins: Design of Glycoclusters with Cyclic Scaffolds as Tools with the Aim to Define Correlations between Spatial Presentation and Activity
Molecules 2013, 18(4), 4026-4053; doi:10.3390/molecules18044026
Received: 11 March 2013 / Revised: 22 March 2013 / Accepted: 1 April 2013 / Published: 4 April 2013
Cited by 37 | PDF Full-text (847 KB) | HTML Full-text | XML Full-text
Abstract
Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages/signals in a minimum of space. The sequence and shape
[...] Read more.
Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages/signals in a minimum of space. The sequence and shape of oligosaccharides as well as spatial aspects of multivalent presentation are assumed to underlie the natural specificity/selectivity that cellular glycans have for endogenous lectins. In order to eventually unravel structure-activity profiles cyclic scaffolds have been used as platforms to produce glycoclusters and afford valuable tools. Using adhesion/growth-regulatory galectins and the pan-galectin ligand lactose as a model, emerging insights into the potential of cyclodextrins, cyclic peptides, calixarenes and glycophanes for this purpose are presented herein. The systematic testing of lectin panels with spatially defined ligand presentations can be considered as a biomimetic means to help clarify the mechanisms, which lead to the exquisite accuracy at which endogenous lectins select their physiological counterreceptors from the complexity of the cellular glycome. Full article
(This article belongs to the Special Issue Calixarenes and Resorcinarenes)

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of the Paper: Review
Title: Calix[n]arenes as Goldmines for the Development of Chemical Entities of Pharmacological Interest
Authors: Eduardo Vinícius Varejão 1, Sergio Antonio Fernandes 1,* and Ângelo de Fátima 2,*
Affiliations: 1 Grupo de Química Supramolecular e Biomimética (GQSB), Departamento de Química, Universidade Federal de Viçosa, Viçosa, MG, 36570-000, Brazil
2 Grupo de Estudos em Química Orgânica e Biológica (GEQOB), Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil
Abstract: Calix[n]arenes are macrocyclic cone-shaped compounds formed by phenolic units linked by methylene groups in ortho position. The structural features make calix[n]arenes a versatile class of molecules of great interest particularly in the pharmaceutical field. The cavity-like shape gives calix[n]arenes the ability to selectively encapsulate ions or neutral molecules, which generates carriers systems capable of increasing the solubility and diffusivity of chemical species. The resulting systems can additionally function as delivers of bioactive guest molecules. This review aims to discuss the biological properties of a variety of calix[n]arenes, focusing their capacity of working as host molecules for improving drug potency, action and/or delivery. The most used spectrometric and spectroscopic methods used to study calix[n]arene inclusion complexes and their effects on solubility, diffusivity and potency of bioactive molecules will be also detailed.


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