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Anti-tumor Effects of Natural Products on Tumor Itself and Tumor...
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Anti-tumor Effects of Natural Products on Tumor Itself and Tumor Microenvironments

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 5353

Special Issue Editor

Prof. Dr. Chang Gue Son

E-Mail Website
Guest Editor
Institute of Traditional Medicine and Bioscience, Daejeon Hospital of Daejeon University, Daejeon, Korea
Interests: anti-tumor drug development; anti-cancer metastasis; tumor microenvironment; natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In addition to conventional therapies such as surgery, radiation, and chemotherapy, molecular targeting therapy and immunotherapy have recently been showing promising results in the treatment of cancerous diseases. Despite persistent research and impressive advances in antitumor therapeutics, cancer is still the leading cause of death worldwide. On the other hand, natural products or compounds from especially medicinal plants, marine plants, and microorganisms are attracting large attention as alternative therapeutics, adjuvant treatments, or chemopreventive agents in control of tumor-associated diseases. In particular, they often show therapeutic effects not only on tumor cells themselves but also on the tumor microenvironments, reducing tumorigenesis, metastatic risk, and the side effects of chemo- and radiotherapy. This Special Issue aims to update our knowledge of the potential therapeutic properties of natural products against both cancer cells and their microenvironments. Studies reporting the anti-tumor effects of natural compounds or herbal plants (single compounds) or/and molecular mechanisms of their actions will be considered for publication.

Prof. Dr. Chang Gue Son
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • tumor
  • herbs
  • natural products
  • bioactive compounds
  • tumor microenvironments
  • metastasis
  • tumorigenesis
  • phytochemicals

Published Papers (2 papers)

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Research

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12 pages, 22396 KiB  
Article
Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic Cells
by Gabriela Piñón-Zárate, Fernanda Reyes-Riquelme, Ma Beatriz Sánchez-Monroy, Mónica Velasco-Torrez, Mariano Martínez-Vázquez, Christian Adrian Cárdenas-Monroy, Beatriz Hernandez-Téllez, Katia Jarquín-Yáñez, Miguel Ángel Herrera-Enríquez and Andrés Eliú Castell-Rodríguez
Molecules 2022, 27(4), 1451; https://doi.org/10.3390/molecules27041451 - 21 Feb 2022
Cited by 4 | Viewed by 2046
Abstract
Dendritic cells are antigen-presenting cells, which identify and process pathogens to subsequently activate specific T lymphocytes. To regulate the immune responses, DCs have to mature by the recognition of TLR ligands, TNFα or IFNγ. These ligands have been used as adjuvants to activate [...] Read more.
Dendritic cells are antigen-presenting cells, which identify and process pathogens to subsequently activate specific T lymphocytes. To regulate the immune responses, DCs have to mature by the recognition of TLR ligands, TNFα or IFNγ. These ligands have been used as adjuvants to activate DCs in situ or in vitro, with toxic effects. It has been shown that some molecules affect the immune system, e.g., Masticadienonic acid (MDA) and 3α-hydroxy masticadienoic acid (3α-OH MDA) triterpenes naturally occurring in several medicinal plants, since they activate the nitric oxide synthase in macrophages and induce T lymphocyte proliferation. The DCs maturation induced by MDA or 3a-OH MDA was determined by incubating these cells with MDA or 3α-OH MDA, and their phenotype was afterwards analyzed. The results showed that only 3α-OH MDA was able to induce DCs maturation. When mice with melanoma were inoculated with DCs/3α-OH MDA, a decreased tumor growth rate was observed along with an extended cell death area within tumors compared to mice treated with DCs incubated with MDA. In conclusion, it is proposed that 3α-OH MDA may be an immunostimulant molecule. Conversely, it is proposed that MDA may be a molecule with anti-inflammatory properties. Full article
(This article belongs to the Special Issue Anti-tumor Effects of Natural Products on Tumor Itself and Tumor Microenvironments)
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Review

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26 pages, 401 KiB  
Review
Recent Advances in the Antiproliferative and Proapoptotic Activity of Various Plant Extracts and Constituents against Murine Malignant Melanoma
by Daria-Antonia Dumitraș and Sanda Andrei
Molecules 2022, 27(8), 2585; https://doi.org/10.3390/molecules27082585 - 17 Apr 2022
Cited by 8 | Viewed by 2779
Abstract
Although conventional medicine, chemical drug synthesis and pharmaceutical research are advancing at a rapid pace, nature remains a major supplier of biological molecules. Natural bioactive compounds are studied closely especially as an alternative to the limitations of conventional therapy in many diseases, melanoma [...] Read more.
Although conventional medicine, chemical drug synthesis and pharmaceutical research are advancing at a rapid pace, nature remains a major supplier of biological molecules. Natural bioactive compounds are studied closely especially as an alternative to the limitations of conventional therapy in many diseases, melanoma being one of them. Malignant melanoma is a highly aggressive type of cancer, and the current methods of treatment used are cryotherapy, external surgery, radiation therapy, chemotherapy, photodynamic therapy, biological therapy, and targeted drug therapy. Unfortunately, these treatment methods are often inefficient, extremely expensive and cause many side effects, which is why focusing on melanoma chemoprevention and adjuvant therapy with natural herbal phytoconstituents is an emerging strategy to prevent, cure or treat melanoma. This review aims to examine the latest discoveries in terms of potential natural bioactive compounds that possess important activity against the development and spread of murine melanoma cancer. In particular, the use of different phytochemicals such as phenolic acids, flavonoids, anthocyanins, terpenoids, essential oils and carotenoids in vitro and in vivo models will be discussed. These data are helpful in guiding researchers in the direction of studying phytonutrients with important effects in the prevention and treatment of melanoma. Full article
(This article belongs to the Special Issue Anti-tumor Effects of Natural Products on Tumor Itself and Tumor Microenvironments)
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