Special Issue "Sample Preparation for Metabolite Analysis"


A special issue of Metabolites (ISSN 2218-1989).

Deadline for manuscript submissions: closed (30 November 2013)

Special Issue Editor

Guest Editor
Dr. Clare A. Daykin
MetaboConsult, Heanor, Derbyshire, DE75 7UY, UK
Website: http://www.metaboconsult.co.uk
E-Mail: clare.daykin@metaboconsult.co.uk
Interests: metabolomics; metabonomics; metabolite-protein interactions; biological sample handling; NMR spectroscopy; chromatography

Special Issue Information

Dear Colleagues,

Sample preparation is a critical, yet often undervalued stage of any metabolomics study. All too often, samples are pre-treated prior to analysis using approaches which have not been optimised, evaluated or validated.

However, previous publications within the area have demonstrated that judicious choice of sample preparation method is critical to analytical success. The choice of sample preparation method not only affects the resultant metabolomic profile of samples, but has even been demonstrated to affect the biochemical conclusions drawn from studies.

In this special issue, I therefore invite authors to share their best practice in the preparation of biological samples for metabolomics.

Dr. Clare A. Daykin
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • sample preparation
  • deproteinisation
  • lipid extraction
  • cell extraction
  • tissue extraction
  • liquid-liquid extraction (LLE)
  • solid phase extraction (SPE)
  • protein precipitation
  • method development
  • off-line SPE
  • on-line SPE
  • metabolic profiles
  • metabolic patterns
  • biomarker detection
  • biomarker validation
  • personalized medicine
  • therapy optimization
  • metabolic modeling
  • metabolic network simulation
  • data integration
  • integrated databases

Published Papers (4 papers)

by , ,  and
Metabolites 2013, 3(3), 592-605; doi:10.3390/metabo3030592
Received: 17 June 2013; in revised form: 17 July 2013 / Accepted: 17 July 2013 / Published: 23 July 2013
Show/Hide Abstract | PDF Full-text (397 KB) | HTML Full-text | XML Full-text

by , , ,  and
Metabolites 2014, 4(1), 71-97; doi:10.3390/metabo4010071
Received: 13 December 2013; in revised form: 14 January 2014 / Accepted: 21 January 2014 / Published: 27 January 2014
Show/Hide Abstract | PDF Full-text (1053 KB) | HTML Full-text | XML Full-text
abstract graphic

by , , , , ,  and
Metabolites 2014, 4(1), 115-128; doi:10.3390/metabo4010115
Received: 2 December 2013; in revised form: 10 January 2014 / Accepted: 7 February 2014 / Published: 19 February 2014
Show/Hide Abstract | PDF Full-text (341 KB) | HTML Full-text | XML Full-text

by , , ,  and
Metabolites 2014, 4(2), 218-231; doi:10.3390/metabo4020218
Received: 31 October 2013; in revised form: 5 March 2014 / Accepted: 11 April 2014 / Published: 22 April 2014
Show/Hide Abstract | PDF Full-text (1003 KB) | HTML Full-text | XML Full-text | Supplementary Files
abstract graphic

Last update: 3 May 2013

Metabolites EISSN 2218-1989 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert