Special Issue "Microbial Metabolomics"


A special issue of Metabolites (ISSN 2218-1989).

Deadline for manuscript submissions: closed (20 September 2013)

Special Issue Editor

Guest Editor
Dr. Walter M. van Gulik
Department of Biotechnology, Kluyver Centre for Genomics of Industrial Fermentation, Delft University of Technology, Delft, The Netherlands
E-Mail: W.M.vanGulik@tudelft.nl
Interests: microbial fermentation, metabolic modeling, metabolomics, systems biology

Special Issue Information

Dear Colleagues,

During the last decade significant progress has been made in the field of quantitative as well as stable isotope based microbial metabolomics, not only with respect to the optimization and validation of sampling, quenching and sample processing methods, but also the improvement of MS based analytics, data processing and mathematical modelling. Next to a further increase of the portfolio of small molecules to be quantified and improvement of the sensitivity and selectivity, is the application of metabolomics to answer intriguing biological questions. Apart from aiming at obtaining a better understanding of the physiology and metabolic regulation of microorganisms in general, these could be focused on the heterogeneity of individuals in clonal populations, cell cycle processes, cell to cell communication, the role of the individual members of microbial communities, compartmentation of metabolic pathways in eukaryotic microbes, solute transport across cellular membranes and so on. This might require the quantification of metabolites in individual cellular compartments and/or in individual cells, which are still big challenges.
This special issue of Metabolites will be dedicated not only to the development of new and the improvement of existing microbial metabolomics techniques, but also to the application of these techniques to tackle intriguing biological questions, thereby integrating metabolomics with other omics data and applying modelling approaches to gain insight in the overwhelming diversity of microbial metabolism, both from a fundamental as well as an applied point of view.

Dr. Walter M. van Gulik
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charges (APC) is waived for well prepared manuscripts in 2012 and starting January 2013, the APC is 300 CHF per accepted paper. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • quantitative metabolomics
  • stable isotopes
  • data processing
  • data integration
  • metabolic modelling
  • compartmentation
  • membrane transport
  • metabolic regulation
  • cell cycle
  • heterogeneity
  • microbial communities

Published Papers (4 papers)

Metabolites 2014, 4(1), 36-52; doi:10.3390/metabo4010036
Received: 13 September 2013; in revised form: 18 December 2013 / Accepted: 20 December 2013 / Published: 31 December 2013
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Metabolites 2013, 3(4), 1118-1129; doi:10.3390/metabo3041118
Received: 8 November 2013; in revised form: 3 December 2013 / Accepted: 6 December 2013 / Published: 13 December 2013
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Metabolites 2013, 3(4), 1102-1117; doi:10.3390/metabo3041102
Received: 15 October 2013; in revised form: 20 November 2013 / Accepted: 25 November 2013 / Published: 6 December 2013
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Metabolites 2013, 3(4), 1076-1083; doi:10.3390/metabo3041076
Received: 24 September 2013; in revised form: 25 October 2013 / Accepted: 1 November 2013 / Published: 11 November 2013
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Last update: 26 March 2013

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