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Metabolites
Special Issues
Metabolomics and Gynaecological Diseases: Unravelling Metabolic Complexities
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Metabolomics and Gynaecological Diseases: Unravelling Metabolic Complexities

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1884

Special Issue Editors

Prof. Dr. Jacopo Troisi

E-Mail
Guest Editor
Department of Medicine Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Fisciano, Italy
Interests: metabolomics; cancer metabolism; metabolomics profiling; endometrial cancer
Dr. Martina Lombardi

E-Mail Website
Guest Editor
Theoreo Srl–spin off company, University of Salerno, Fisciano, Italy
Interests: metabolomics; cancer metabolism; metabolomics profiling; endometrial cancer

Special Issue Information

Dear Colleagues,

The past few decades have witnessed a concerning increase in the prevalence of several gynaecological diseases worldwide, posing significant health challenges to women. Understanding their underlying mechanisms is crucial for developing effective diagnostic and treatment strategies.

As metabolomics presents a promising avenue for unravelling the complex metabolic alterations associated with these conditions, we are excited to announce the launch of a Special Issue that aims to explore the role of metabolomics in advancing our knowledge of gynaecological diseases.

This Special Issue seeks original contributions that shed light on key aspects of gynaecological disease biology. We welcome research that delves into the metabolic changes induced by oncogenic mutations in gynaecological malignancies. Additionally, studies elucidating the cellular response to bioactive compounds in the context of gynaecological diseases are of great interest.

Understanding the role of metabolic pathways in acquired resistance to anticancer agents and other therapeutic interventions is another area of exploration we encourage. Furthermore, research focused on identifying metabolites that could serve as biomarkers for the screening, diagnosis, and monitoring of gynaecological diseases is highly relevant to this Special Issue.

In addition to original research articles, we also invite literature reviews that provide insightful overviews of the current state of metabolomics research in the field of gynaecology. Moreover, innovative studies that employ multi-omics approaches to gain a comprehensive understanding of gynaecological disease biology are welcome.

Our aim with this Special Issue is to foster collaboration and knowledge sharing among researchers working to unravel the metabolic intricacies of gynaecological diseases. By bringing together cutting-edge research in metabolomics, we hope to pave the way for improved diagnostic techniques and targeted therapeutic interventions.

We look forward to receiving your valuable contributions to this comprehensive exploration of metabolomics studies in gynaecological diseases.

Prof. Dr. Jacopo Troisi
Dr. Martina Lombardi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynaecological diseases
  • metabolomics profiling
  • multi-omics approach
  • biomarker
  • personalised medicine
  • cancer metabolism

Published Papers (1 paper)

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Research

18 pages, 4183 KiB  
Article
Metabolomic Profiling of Blood Plasma in Females with Hyperplasia and Endometrial Cancer
by Hicham Benabdelkamel, Malak A. Jaber, Khalid Akkour, Reem H. AlMalki, Assim A. Alfadda, Afshan Masood, Salini Scaria Joy, Hani Alhalal, Moudi A. Alwehaibi, Maria Arafah, Eman Alshehri and Anas M. Abdel Rahman
Metabolites 2024, 14(2), 109; https://doi.org/10.3390/metabo14020109 - 6 Feb 2024
Viewed by 1562
Abstract
Uterine cancer is the most prevalent gynecologic malignancy in women worldwide. Endometrial cancer (EC) has an 81% five-year survival rate, depending on disease stage and time of diagnosis. While endometrial cancer is largely treatable when detected early, no established screening techniques are available [...] Read more.
Uterine cancer is the most prevalent gynecologic malignancy in women worldwide. Endometrial cancer (EC) has an 81% five-year survival rate, depending on disease stage and time of diagnosis. While endometrial cancer is largely treatable when detected early, no established screening techniques are available in clinical practice. As a result, one of the most significant issues in the medical field is the development of novel ways for early cancer identification, which could boost treatment success rates. Liquid chromatography–high-resolution mass spectrometry (LC-HRMS)-based metabolomics was employed to explore the metabolomic markers and pathways unique to this cancer type and link them to the benign endometrial hyperplasia that may progress to cancer in 5% to 25% of patients. The study involved 59 postmenopausal participants, 20 with EC type 1, 20 with benign hyperplasia, and 19 healthy participants. Metabolite distribution changes were analyzed, and 338 of these features were dysregulated and significant. The first two main components, PC1 and PC2, were responsible for 11.5% and 12.2% of the total metabolites, respectively. Compared with the control group (CO), EC samples had 203 differentially expressed metabolites (180 upregulated and 23 downregulated); in hyperplasia (HP), 157 metabolites were dysregulated (127 upregulated and 30 downregulated) compared to the CO group while 21 metabolites exhibited differential regulation (16 upregulated and 5 downregulated) in EC plasma samples compared to the HP group. Hyperplasia samples exhibited similar metabolic changes to those reported in cancer, except for alterations in triglyceride levels, 7a,12 b-dihydroxy-5b-Cholan-24-oic acid, and Hept-2-enedioyl carnitine levels. The metabolites N-heptanoyl glycine and -(Methylthio)-2,3-isopentyl phosphate and formimino glutamic acid can be specific markers for hyperplasia conditions and dimethyl phosphatidyl ethanolamine and 8-isoprostaglandin E2 can be specific markers for EC conditions. Metabolic activities rely on mitochondrial oxidative phosphorylation for energy generation. The changes in metabolites identified in our study indicate that endometrial cancer cells adopt alternative strategies to increase energy production to meet the energy demand, thereby supporting proliferation. Full article
(This article belongs to the Special Issue Metabolomics and Gynaecological Diseases: Unravelling Metabolic Complexities)
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