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Metabolites
Special Issues
Nutrients and Metabolic Syndrome
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Nutrients and Metabolic Syndrome

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (15 December 2020) | Viewed by 3525

Special Issue Editors

Dr. Frances M Wolber

E-Mail Website
Guest Editor
School of Food and Nutrition, Massey University, Palmerston North, New Zealand
Interests: metabolic syndrome; immunity and inflammation; micronutrients; cancer; bone and joint health
Prof. Rachel Page

E-Mail Website
Guest Editor
School of Health Sciences, Massey University, Wellington, New Zealand
Interests: metabolic health; health literacy and education; diagnostic biomarkers; chronic diseases
Dr. Sharon Henare

E-Mail Website
Guest Editor
Riddet Institute, Te Ohu Rangahau Kai, Massey University
Interests: gastrointestinal and reproductive physiology; satiety; protein and fiber digestion; endocrinology

Special Issue Information

Dear Colleagues,

Metabolic syndrome is a cluster of chronic conditions that leads to an increased risk of cardiovascular disease and diabetes. With a growing prevalence even in non-Western countries due to unhealthy lifestyles, metabolic syndrome is now a major global health burden. Total diet, as well as individual foods, macronutrients, and micronutrients, are implicated in both the development and treatment of metabolic syndrome. This Special Issue is focused on the role of nutrients in metabolic syndrome itself as well as in the disorder’s individual characteristics of hypertension, hyperlipidemia, insulin resistance, and abdominal obesity.

Research articles from both in vitro and in vivo studies are welcome, as are review articles reporting on the nexus between nutrients and metabolic syndrome. Articles describing the use of new genomic tools such as metabolomics and other “omics” methods, prospective diagnostic biomarkers, or nutrient-based intervention strategies would complete the topic.

Dr. Frances M Wolber
Prof. Rachel Page
Dr. Sharon Henare
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metabolic syndrome
  • obesity
  • cardiovascular disease
  • diabetes
  • diet
  • nutrients
  • food

Published Papers (1 paper)

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Research

15 pages, 1874 KiB  
Article
Metabolic Signatures of Gestational Weight Gain and Postpartum Weight Loss in a Lifestyle Intervention Study of Overweight and Obese Women
by Chung-Ho E. Lau, Victoria Taylor-Bateman, Panagiotis A. Vorkas, Gonçalo Graça, Thanh-Huyen T. Vu, Lifang Hou, Elena Chekmeneva, Timothy M. D. Ebbels, Queenie Chan, Linda Van Horn and Elaine Holmes
Metabolites 2020, 10(12), 498; https://doi.org/10.3390/metabo10120498 - 4 Dec 2020
Cited by 4 | Viewed by 3113
Abstract
Background: Overweight and obesity amongst women of reproductive age are increasingly common in developed economies and are shown to adversely affect birth outcomes and both childhood and adulthood health risks in the offspring. Metabolic profiling in conditions of overweight and obesity in pregnancy [...] Read more.
Background: Overweight and obesity amongst women of reproductive age are increasingly common in developed economies and are shown to adversely affect birth outcomes and both childhood and adulthood health risks in the offspring. Metabolic profiling in conditions of overweight and obesity in pregnancy could potentially be applied to elucidate the molecular basis of the adverse effects of gestational weight gain (GWG) and postpartum weight loss (WL) on future risks for cardiovascular disease (CVD) and other chronic diseases. Methods: Biofluid samples were collected from 114 ethnically diverse pregnant women with body mass index (BMI) between 25 and 40 kg/m2 from Chicago (US), as part of a randomized lifestyle intervention trial (Maternal Offspring Metabolics: Family Intervention Trial; NCT01631747). At 15 weeks, 35 weeks of gestation, and at 1 year postpartum, the blood plasma lipidome and metabolic profile of urine samples were analyzed by liquid chromatography mass spectrometry (LC-MS) and 1H nuclear magnetic resonance spectroscopy (1H NMR) respectively. Results: Urinary 4-deoxyerythronic acid and 4-deoxythreonic acid were found to be positively correlated to BMI. Seventeen plasma lipids were found to be associated with GWG and 16 lipids were found to be associated with WL, which included phosphatidylinositols (PI), phosphatidylcholines (PC), lysophospholipids (lyso-), sphingomyelins (SM) and ether phosphatidylcholine (PC-O). Three phospholipids found to be positively associated with GWG all contained palmitate side-chains, and amongst the 14 lipids that were negatively associated with GWG, seven were PC-O. Six of eight lipids found to be negatively associated with WL contained an 18:2 fatty acid side-chain. Conclusions: Maternal obesity was associated with characteristic urine and plasma metabolic phenotypes, and phospholipid profile was found to be associated with both GWG and postpartum WL in metabolically healthy pregnant women with overweight/obesity. Postpartum WL may be linked to the reduction in the intake of linoleic acid/conjugated linoleic acid food sources in our study population. Full article
(This article belongs to the Special Issue Nutrients and Metabolic Syndrome)
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