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Special Issue "Nanomaterials for Biomedical Applications"

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (30 November 2017)

Special Issue Editors

Guest Editor
Prof. Dr. Anne Marie Healy

Pharmaceutics and Pharmaceutical Technology, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland
Website | E-Mail
Interests: pharmaceutical material science; preformulation and formulation of pharmaceuticals; amorphous solids; co-crystals; formulating poorly soluble drugs; pharmaceutical processing; pulmonary drug delivery and formulation stability
Guest Editor
Assist. Prof. Eduardo Ruiz-Hernandez

Pharmaceutical Chemistry of Nanocarrier Drug Delivery Systems, School of Pharmacy and Pharmaceutical Sciences - Panoz Institute, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland
Website | E-Mail
Interests: nanomedicine; materials chemistry; drug/gene delivery; tissue engineering
Guest Editor
Assist. Prof. Juan Luis Vivero-Escoto

Department of Chemistry, College of Liberal Arts & Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Website | E-Mail
Interests: organic/materials chemistry

Special Issue Information

Dear Colleagues,

Nanomaterials have recently become one of the most active research fields in the areas of engineering, chemistry, solid state physics, biotechnology and biomedicine. One reason for this interest is that nanomaterials display novel and often enhanced properties compared to traditional materials, which opens up the potential for new technological applications. The use of nanomaterials in the biomedical field presents many revolutionary opportunities in the fight against all kinds of cancer, cardiac and neurodegenerative disorders, infection and other diseases. The nanoparticle platforms that have been extensively explored for biomedical applications are predominantly either purely inorganic or organic materials. For example organic nanomaterials such as nanocrystals, liposomes, dendrimers, hyper-branched organic polymers, micelles and polymeric hydrogel nanoparticles have been widely used as imaging and therapeutic agents. Recently, inorganic nanomaterials such as quantum dots, superparamagnetic iron oxide nanoparticles, metallic nanoparticles and metal oxides have also attracted great attention for biomedical applications.

In another relevant example, hybrid nanoparticles are composed of both inorganic and organic components that can not only retain the beneficial features of both inorganic and organic nanomaterials, but also possess unique advantages over the other two types. For instance, the ability to combine a multitude of organic and inorganic components in a modular fashion allows for systematic tuning of the properties for biomedical applications. Hybrid nanoparticles have been proposed for the targeted release of diagnostic agents and drugs, and even as stimuli responsive nanocarriers to enhance therapy selectivity. The combination of these materials with current efforts to identify genes, proteins and metabolites implicated in human disease and use system biology approaches to develop new prognostic tools and more targeted therapies for patients, will dramatically impact healthcare in the coming years.

This Special Issue focuses on the use of organic/inorganic or hybrid nanomaterials for biomedical applications. We invite full papers, communications and reviews covering one or several of the topics included in (or related to) the keywords below.

Prof. Dr. Anne Marie Healy
Asstis. Prof. Eduardo Ruiz-Hernandez
Asstit. Prof. Juan Luis Vivero-Escoto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • drug delivery
  • biosensing
  • biomedical imaging
  • diagnostics
  • tissue regeneration
  • cancer
  • infection
  • cardiovascular diseases
  • pulmonary diseases
  • protein delivery
  • gene delivery
  • photodynamic therapy
  • photothermal therapy
  • theranostics
  • magnetic hyperthermia
  • nanoparticle manufacture and processing

Published Papers (1 paper)

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Open AccessArticle Direct Synthesis of Carbon Nanotube Field Emitters on Metal Substrate for Open-Type X-ray Source in Medical Imaging
Materials 2017, 10(8), 878; doi:10.3390/ma10080878
Received: 13 June 2017 / Revised: 3 July 2017 / Accepted: 27 July 2017 / Published: 29 July 2017
PDF Full-text (3409 KB) | HTML Full-text | XML Full-text
We report the design, fabrication and characterization of a carbon nanotube enabled open-type X-ray system for medical imaging. We directly grew the carbon nanotubes used as electron emitter for electron gun on a non-polished raw metallic rectangular-rounded substrate with an area of 0.1377
[...] Read more.
We report the design, fabrication and characterization of a carbon nanotube enabled open-type X-ray system for medical imaging. We directly grew the carbon nanotubes used as electron emitter for electron gun on a non-polished raw metallic rectangular-rounded substrate with an area of 0.1377 cm2 through a plasma enhanced chemical vapor deposition system. The stable field emission properties with triode electrodes after electrical aging treatment showed an anode emission current of 0.63 mA at a gate field of 7.51 V/μm. The 4.5-inch cubic shape open type X-ray system was developed consisting of an X-ray aperture, a vacuum part, an anode high voltage part, and a field emission electron gun including three electrodes with focusing, gate and cathode electrodes. Using this system, we obtained high-resolution X-ray images accelerated at 42–70 kV voltage by digital switching control between emitter and ground electrode. Full article
(This article belongs to the Special Issue Nanomaterials for Biomedical Applications)

Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Article type: Review
Local chemotherapy drug delivery systems for the treatment of glioblastoma multiforme
Eduardo Ruiz-Hernandez et al.

Title: 3D Printing of Nanogels for Biomedical Applications
Authors: Hyunah Cho 1, Austin Chen 1, Dip Patel 1, Karthik tappa 2, Uday Bhanu 2 and Jeffery Weisman 2
Affiliation: 1 St. Louis College of Pharmacy
2 Washington University in St. Louis
Abstract: Nanogels are attractive biocompatible materials, which mimic bio-environment, enable delivery of m ulti-drugs, absorb water to swell and gradually release the drug payloads at the site of application. While nanogels have several advantages as biomedical materials, they are often not well-suited for consistent production. Advancements in 3D printing technology has led to high precision, high efficiency, high reproducibility, and convenient operations, which may allow for the creation of patient-specific and rationally-designed biomedical materials or devices including nanogels. Here, we propose to review and summarize recent development of nanogels using 3D printing technology.

Title: The Role of Mucin in the Toxicological Impact of Polystyrene Nanoparticles
Authors: Iwona Inkielewicz-Stepniak 1, Lidia Tajber 2, Marek W Radomski 3, Carlos Medina 2,4 and Maria J. Santos-Martinez 2,4,5
Affiliation: 1 Department of Medical Chemistry, Medical University of Gdansk, Poland
2 School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland
3 College of Medicine, University of Saskatchewan, Canada
4 Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland
5 School of Medicine, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland

Title: Anticancer Applications of Nanostructured Silica-Based Materials Functionalized with Titanocene Derivatives: Induction of Cell Death Mechanism through TNFR1 Modulation
Authors: Alberto García-Peñas 1, Sanjiv Prashar 1, Eva Fischer-Fodor 2,3 and Santiago Gómez-Ruiz 1
Affiliation: 1 Departamento de Biología y Geología, Física y Química Inorgánica, ESCET, Universidad Rey Juan Carlos, Calle Tulipán s/n, E-28933, Móstoles (Madrid), Spain
2 Medfuture-Research Center for Advanced Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, RO-400337, Cluj-Napoca, Romania
3 Tumor Biology Department, The Oncology Institute "I.Chiricuta", RO-400015, Cluj-Napoca, Romania

Title: Biopolymer-based nanoparticles for lung cystic fibrosis gene therapy studies
Authors: Fernández Fernández E 1,3, Santos-Carballal B 2, de Santi C 1, Ramsey J 3, Cryan SA 3, Greene CM 1
Affiliation: 1 Lung Biology Group, Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
2 ChiPro GmbH, Anne-Conway-Straße 1, 28359, Bremen, Germany
3 School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland
Abstract: Lung gene therapy for cystic fibrosis disease has not been successful due to several challenges such as the absence of an appropriate vector. Therefore, the optimal delivery of newer therapeutic approaches to airway epithelial cells demands suitable non-viral systems in order to reduce potential host immune responses. In this work, we describe the formulation and the bio/physicochemical investigation of biocompatible and biodegradable polymeric nanoparticles (NPs), including PLGA and chitosan (animal and vegetal), as a novel method for the safe and efficient delivery of CFTR-specific locked nucleic acids (LNAs).

Title: Fabrication of precisely-defined nanomaterials via advanced manufacturing techniques for translational applications
Authors: Peipei Zhang 1 and Chelsea Ryan Virgile 2
Affiliations: 1 Beijing Aerospace University
2 University of Maryland College Park
Abstract: Nanomaterials have shown great potentials in biomedical applications. Most nanomaterials are generated via bottom-up technologies—techniques that assemble nanomaterials from small building blocks such as chemical molecules. These methods, while useful by producing nanomaterials in a large batch, have very limited flexibility in controlling materials properties such as size, surface property, cargo loading, etc. As a contrast, advanced manufacturing techniques such as photolithography, soft lithography and layer-by-layer assembly allows fabricating nanomaterials with highly controllable features, enabling unique translational studies and applications. Here in this work, we will review the existing technologies that employ advanced manufacturing techniques for generating nanomaterials with precisely defined characteristics, as well as their translational application. We will also address the advantages of these highly controlled nanomaterials as compared to conventional materials in biomedical applications.

Title: Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus
Authors: Alan Hibbitts 1,2,3,* and Cian O’Leary 1,2,3,4,*
Affiliations: 1 Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland
2 Trinity Centre for Bioengineering, Trinity College Dublin (TCD), Dublin, Ireland
3 Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI and TCD, Dublin, Ireland
4 School of Pharmacy, RCSI, Dublin, Ireland
* Denotes equal contribution
Abstract: In a recent report, the World Health Organisation (WHO) classified antibiotic resistance as one of the greatest threats to global health, food security, and development. Methicillin-resistant Staphylococcus aureus (MRSA) remains at the core of this threat, with persistent and resilient strains detectable in up to 90% of S. aureus infections. Unfortunately, there is a lack of novel antibiotics reaching the clinic to address the significant morbidity and mortality that MRSA is responsible for. Recently, nanomedicine strategies have emerged as a promising therapy to combat the rise of MRSA. However, these approaches have been wide-ranging in design with few attempts to compare studies across scientific and clinical disciplines. This review seeks to reconcile this discrepancy in the literature, with specific focus on the mechanisms of MRSA infection and how they can be exploited by bioactive molecules delivered by nanomedicines, in addition to utilisation of the nanomaterials themselves as antibacterial agents. Finally, we discuss targeting MRSA biofilms using nano-patterning technologies and comment on future opportunities and challenges for MRSA treatment using nanomedicine.

Title: Nanoparticles for sensing and medical diagnostic applications
Authors: Luigi La Spada et al.
Abstract: A modeling and design approach is proposed for nanoparticle-based electromagnetic devices. First, the structure properties will be analytically studied by using classical electromagnetic theory based on Maxwell’s equations. The proposed model provides us the possibility to correlate the nanoparticle electromagnetic properties (amplitude, phase and bandwidth) with its geometrical characteristics (shape, geometry, dimensions) Secondly, new designs based on “metamaterial” concept are proposed, demonstrating great performances in terms of wide-angle range functionality, multi-band and wide-band behavior, compared to conventional devices working at the same frequencies. The approach offers potential applications to build-up new advanced platforms for sensing and medical diagnostics. Therefore, in the third and final part of the article some practical examples will be reported such as cancer detection, water content measurements and chemical analysis (glucose concentration measurements and blood diseases monitoring).

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