Next Article in Journal
Selenium-Containing Polysaccharide-Protein Complex in Se-Enriched Ulva fasciata Induces Mitochondria-Mediated Apoptosis in A549 Human Lung Cancer Cells
Next Article in Special Issue
Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats
Previous Article in Journal
Synthesis of Poly(norbornene-methylamine), a Biomimetic of Chitosan, by Ring-Opening Metathesis Polymerization (ROMP)
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Mar. Drugs 2017, 15(7), 224; doi:10.3390/md15070224

Inhibitory Growth of Oral Squamous Cell Carcinoma Cancer via Bacterial Prodigiosin

1
Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 10086, Taiwan
2
Division of Histology and Clinical Pathology, Hualian Army Forces General Hospital, Hualien 97144, Taiwan
3
Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei 10086, Taiwan
4
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan
5
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 94450, Taiwan
6
National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan
*
Author to whom correspondence should be addressed.
Received: 11 May 2017 / Revised: 2 July 2017 / Accepted: 13 July 2017 / Published: 15 July 2017
(This article belongs to the Special Issue Development and Application of Herbal Medicine from Marine Origin)
View Full-Text   |   Download PDF [3465 KB, uploaded 15 July 2017]   |  

Abstract

Chemotherapy drugs for oral cancers always cause side effects and adverse effects. Currently natural sources and herbs are being searched for treated human oral squamous carcinoma cells (OSCC) in an effort to alleviate the causations of agents in oral cancers chemotherapy. This study investigates the effect of prodigiosin (PG), an alkaloid and natural red pigment as a secondary metabolite of Serratia marcescens, to inhibit human oral squamous carcinoma cell growth; thereby, developing a new drug for the treatment of oral cancer. In vitro cultured human OSCC models (OECM1 and SAS cell lines) were used to test the inhibitory growth of PG via cell cytotoxic effects (MTT assay), cell cycle analysis, and Western blotting. PG under various concentrations and time courses were shown to effectively cause cell death and cell-cycle arrest in OECM1 and SAS cells. Additionally, PG induced autophagic cell death in OECM1 and SAS cells by LC3-mediated P62/LC3-I/LC3-II pathway at the in vitro level. These findings elucidate the role of PG, which may target the autophagic cell death pathways as a potential agent in cancer therapeutics. View Full-Text
Keywords: prodigiosin; marine viva; autophage; oral squamous cell carcinoma prodigiosin; marine viva; autophage; oral squamous cell carcinoma
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cheng, M.-F.; Lin, C.-S.; Chen, Y.-H.; Sung, P.-J.; Lin, S.-R.; Tong, Y.-W.; Weng, C.-F. Inhibitory Growth of Oral Squamous Cell Carcinoma Cancer via Bacterial Prodigiosin. Mar. Drugs 2017, 15, 224.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top