Special Issue "Biomaterials Approaches for Cancer Research"


A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (20 August 2014)

Special Issue Editor

Guest Editor
Dr. Sue Anne Chew
Department of Biomedicine, University of Texas at Brownsville, One West University Blvd, Brownsville, TX 78520, USA
Website: http://utb.edu/vpaa/cbshp/bs/Pages/SueAnneChew.aspx
E-Mail: SueAnne.Chew@utb.edu
Interests: biomaterials for the study and treatment of cancer and tissue engineering

Special Issue Information

Dear Colleagues,

Over the years, the field of biomaterials has emerged as an important tool in the fight against cancer. Biomaterials approaches are applied to improve methods of studying cancer in vitro. Different materials are used to create 3D cell culture systems, which can act as intermediate stages between 2D culture and animal models. Biomaterials are also currently used in the detection and diagnosis of cancer; such diagnostics include the development of biomaterials-based immunoassays, which detect biomarkers and biomaterials to facilitate the delivery of contrast agents for imaging. Furthermore, biomaterials also play an integral role in the advancement of cancer therapies. A wide spectrum of biomaterials are being applied for the targeted and sustained delivery of therapeutic agents. Due to the difficulties and high costs of developing new therapeutics and detection and diagnosis methods, focus should be placed on applying biomaterials that optimize currently available approaches. Biomaterial properties, such as size, shape, charge, surface chemistry, morphology, and physiochemical properties can be easily tailored to tackle specific challenges in cancer. Thus, biomaterials enable useful, innovative approaches for improving the current technologies available for studying, detecting, and treating cancer.

Dr. Sue Anne Chew
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.

Special Issue Flyer

Please download the special issue flyer here.


  • cancer therapy
  • cancer detection and diagnosis
  • 3d culture systems
  • drug delivery
  • imaging

Published Papers (1 paper)

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p. 167-182
by , , ,  and
J. Funct. Biomater. 2014, 5(3), 167-182; doi:10.3390/jfb5030167
Received: 24 May 2014; in revised form: 26 July 2014 / Accepted: 28 July 2014 / Published: 16 September 2014
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(This article belongs to the Special Issue Biomaterials Approaches for Cancer Research)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Article
Insights and Relative Effect of Aspirin, Naproxen and Ibuprofen Chitosan-Vitamin C Containing Hydrogels: As a Prototype Functional Wound Healing Restorative Material and Build in Free Radical Defense: In-Vitro Studies
V. Tamara Perchyonok 1,*, Shengmiao Zhang 2, Sias R. Grobler 3
1 VTPCHEM PTY LTD, Gold Coast, Southport, 4215, QLD, Australia
School of Material Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
Oral and Dental Research Institute, Faculty of Dentistry, University of the Western Cape, Private Bag X1, Tygerberg 7505, Cape Town, South Africa
Wound healing is the process including phases of homeostasis, inflammation, proliferation and remodeling as well as many biochemical and cellular mechanisms. It has been suggested that the anti-inflammatory activity of some non-steroidal anti-inflammatory drugs (NSAIDs) may be partly due to their ability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as to inhibit the respiratory burst of neutrophils triggered by various activating agents. As a part of our continuous interest of developing functional dual action restorative materials capable of being “bio-active” and wound healing, we designed and evaluate novel chitosan hydrogels containing krill oil (antioxidant containing material), naproxen, ibuprofen (non steroidal anti-inflammatory medication), aspirin (pain relieve medication and free radical scavengers) and combinations thereof (chitosan-Vitamin C-krill oil, chitosan-VitC-krill oil-aspirin and chitosan-VitC-naproxen, chitosan-Vit C-naproxen-krill oil, chitosan-VitC-krill oil-ibuprofen and chitosan-VitC-ibuprofen) as functional additive prototypes for further development of ”dual function restorative materials,” secondly to determine their effect on the dentin bond strength of a composite and thirdly evaluate the capability of newly designed hydrogels to play an integral role of “build in free radical defense mechanism by using BSA  solubility as a “molecular prototype of the site of free radical attack in vitro.  Structural features of interactions of free radical generated and “build defense mechanism” are monitored by SEM in order to gain insight into the reaction profile.

Last update: 21 May 2014

J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert