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J. Funct. Biomater. 2015, 6(1), 81-103; doi:10.3390/jfb6010081

Modulation of the Tumor Microenvironment for Cancer Treatment: A Biomaterials Approach

Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
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Author to whom correspondence should be addressed.
Academic Editor: Sue Anne Chew
Received: 23 September 2014 / Revised: 7 October 2014 / Accepted: 12 February 2015 / Published: 17 February 2015
(This article belongs to the Special Issue Biomaterials Approaches for Cancer Research)
View Full-Text   |   Download PDF [784 KB, uploaded 17 February 2015]   |  

Abstract

Tumors are complex tissues that consist of stromal cells, such as fibroblasts, immune cells and mesenchymal stem cells, as well as non-cellular components, in addition to neoplastic cells. Increasingly, there is evidence to suggest that these non-neoplastic cell components support cancer initiation, progression and metastasis and that their ablation or reprogramming can inhibit tumor growth. Our understanding of the activities of different parts of the tumor stroma in advancing cancer has been improved by the use of scaffold and matrix-based 3D systems originally developed for regenerative medicine. Additionally, drug delivery systems made from synthetic and natural biomaterials deliver drugs to kill stromal cells or reprogram the microenvironment for tumor inhibition. In this article, we review the impact of 3D tumor models in increasing our understanding of tumorigenesis. We also discuss how different drug delivery systems aid in the reprogramming of tumor stroma for cancer treatment. View Full-Text
Keywords: 3D tumor model; mesenchymal stem cells; nanocarriers; immune reprogramming; tumor stroma 3D tumor model; mesenchymal stem cells; nanocarriers; immune reprogramming; tumor stroma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Adjei, I.M.; Blanka, S. Modulation of the Tumor Microenvironment for Cancer Treatment: A Biomaterials Approach. J. Funct. Biomater. 2015, 6, 81-103.

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