Effects of Metal Ion Exposure from Joint Prostheses on Organ Systems
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: closed (31 December 2018) | Viewed by 3774
Special Issue Editor
Interests: joint replacement; epidemiology of implant–host interactions; genetics of musculoskeletal disease; disease biomarkers; metabolic bone disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
All metal-containing joint replacement prostheses release metal debris into the local and systemic tissue environments. This debris arises as a result of wear and corrosion at the prosthesis surfaces. Local adverse tissue responses to this released metal have resulted in a substantially higher prosthesis failure rate in prostheses using cobalt–chromium at the bearing surfaces and other modular interfaces. Case reports of severe systemic illness involving cardiac, neurological, and other distant organ systems have also been associated with excessive wear or corrosion of cobalt–chromium alloy-containing prostheses. Despite this burden of clinical disease associated with metal ion exposure, the magnitude of the underlying risk associated with metal-on-metal bearings and interfaces remains unclear and the relevant molecular pathways are poorly characterized.
This Special Issue of the International Journal of Molecular Sciences will focus on recent advances in our understanding of “Adverse Reactions to Metal Debris”, including new insights into the epidemiology as it relates to disease mechanisms, pathogenesis, and molecular biology of ARMD. The issue will include articles addressing both adverse responses at the local tissue level and those addressing the effects at distant organ sites. Topics will include those exploring the relationship between magnitude of exposure and disease burden, the spectrum of organ systems that may be implicated, toxicology, disease biomarkers, and the biological mechanisms that underpin the observed pathologies.
Prof. Dr. Mark Wilkinson
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cobalt
- chromium
- exposure
- adverse response to metal debris
- epidemiology
- pathogenesis
- biomarker
- toxicology
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.