Special Issue "Glycan–Receptor Interaction 2018"
Deadline for manuscript submissions: 25 September 2018
Prof. Dr. Cheorl-Ho Kim
Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, College of Science, Sungkyukwan University, 2066, Seobu-Ro, Jangan-Gu, Suwon-Si, Gyeong Gi, Korea
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Interests: glycobiology; sialobiology; sialyltransferase; N-glycan; O-glycan; glycolipid; sphingolipid; glycoprotein; surface sugar; ganglioside; sialic acid; sialyl Le antigen; lectin; galectin; siglec; ER-Golgi glyosylation; sugar–receptor interaction; innate immune; xenotransplantation; cell–cell interaction
Cell surface carbohydrates attached to proteins and lipids are major components of the outer surface of mammalian cells. Changes to the surface glycosylation are important means of cell–cell interaction in fertilization, development, differentiation, growth, aging, adhesion, signal transduction, neurotransduction, immune systems, and carcinogenesis, metastasis, and angiogenesis. Therefore, surface glycosylations are mainly located on the borders of cells to communicate through face-to-face recognition or carbohydrate glycan–receptor interaction. Because the glycans communicate with their counterparts, such as specific receptors through purely physical interactions, the synthesis and distribution of these components are under strict genetic control. These glycosylated proteins and lipids have been implicated in multicellular functional expression and society formation, which depends on cell type, tissue type, and organ type. Modifications of cellular glycosylation are also a common phenotypic change in malignancy, with a poor prognosis for the patients. Most of the carbohydrate tumor antigens are sialylated. As examples, the mucin-type Sialyl-Tn, Sialyl-Lewis X, and Sialyl-Lewis A antigens are increased in the N-linked and O-linked oligosaccharides of the carcinoma cell glycoproteins of cancers. In recent viral pandemics, it was recognized that human and avian influenza viruses bind sialic acid-based receptors. For example, a human-type is NeuAcα2-6Gal, while an avian-type is NeuAcα2-3Gal. From the recent human type H3N2 virus, the evolutionary transition has been suggested in sialyl ligand–receptor interaction. Therefore, interaction between the influenza virus and sialic acid receptors is the hot issue of current glycan–receptor interaction. The changed glycans can regulate carbohydrate–carbohydrate, carbohydrate–protein, and carbohydrate–lipid interactions. Therefore, each glycan structure has been implicated as a face or signature of certain biological states in cells and organs. In tumors, the glycosylated antigens can be used as tumor markers for human cancer patients, especially for node-negative patients.
We invite researchers to contribute original and review articles regarding the interactions between glycans and proteins. Potential topics include, but are not limited to:
- Glycosylation of N-/O-glycoproteins
- Sialylation of glycoproteins and glycolipids
- Lectin–glycan interaction
- Glycosylation in malignancy and cancers
- Xenoantigenic glycosylation in non-human mammals
- Sphingolipids in membranes
- ER-specific glycobiology
- Golgy-specific glycobiology
- Glycan-based cell differentiation and development
- Glycan antigens in stem cells
- Sialyl antigen–Lectin, Galectin, Siglec
- Sugar–receptor interaction
- Innate immunity
- Influenza virus and sialic acid receptors
- Sialic acids mimetics as drug design
Prof. Dr. Cheorl-Ho Kim
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Surface Glycan
- ER–Golgi network
- Glycan–receptor interaction
- Innate Immunity
- Cell–cell interaction
- Influenza virus sialic acid receptors