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Novel Molecular Pathways in Oncology, 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 2415

Special Issue Editor

Special Issue Information

Dear Colleagues,

Oncology research continues to reveal the molecular signatures that define tumor characteristics and behavior, with the focus increasingly shifting toward the complex molecular pathways implicated in tumorigenesis, cancer cell proliferation, inflammation and angiogenesis, tissue infiltration, and dissemination to distant sites. New research should focus on better investigating the molecular mechanisms that promote cancer and on the development of efficient therapeutic and pharmacological interventions. For this Special Issue, we welcome research and review articles focusing on the diverse molecular mechanisms implicated in different steps of carcinogenesis, which could serve as therapeutic targets.

Dr. Giovanna Casili
Guest Editor

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Keywords

  • molecular pathway involved in tumorigenesis
  • cancer therapy
  • targeted therapy
  • anticancer drugs
  • brain cancer
  • oral cancer
  • gastrointestinal cancer

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Published Papers (2 papers)

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Research

15 pages, 3764 KiB  
Article
Apoptosis-Inducing and Proliferation-Inhibiting Effects of Doramectin on Mz-ChA-1 Human Cholangiocarcinoma Cells
by Yunfang Zhang, Wei Wu, Yan Shi, Yuehong Huang, Ting Dai, Lina Ke, Lizhu Chen, Mingliang Chen and Qin Wang
Int. J. Mol. Sci. 2024, 25(24), 13440; https://doi.org/10.3390/ijms252413440 - 15 Dec 2024
Viewed by 946
Abstract
Cholangiocarcinoma is a malignant tumor that emerges in the intrahepatic or extrahepatic bile ducts. Doramectin (DOR), a third-generation derivative of avermectins (AVMs), is renowned for its low toxicity and high efficiency. However, no research has hitherto focused on the anti-cholangiocarcinoma effects of these [...] Read more.
Cholangiocarcinoma is a malignant tumor that emerges in the intrahepatic or extrahepatic bile ducts. Doramectin (DOR), a third-generation derivative of avermectins (AVMs), is renowned for its low toxicity and high efficiency. However, no research has hitherto focused on the anti-cholangiocarcinoma effects of these drugs. In this study, we undertook a preliminary exploration of the mechanism through which DOR inhibits the viability of human cholangiocarcinoma cells (Mz-ChA-1) via transcriptome analysis and molecular validation at the cellular level. The results indicated that DOR could suppress the growth and proliferation of Mz-ChA-1 cells in a dose-dependent manner. Moreover, it significantly diminished their migration and invasion abilities. Cell cycle analysis disclosed arrest in the G1 phase, accompanied by an increase in p21 expression and a decrease in the levels of the cyclin E1 and CDK2 proteins. Additionally, DOR induced apoptosis via the ROS-triggered mitochondrial pathway. This was attested by an elevation in the BAX/BCL-2 ratio, the activation of caspase 3/7 and the cleavage of PARP1. These mechanistic insights underscore DOR’s potential as a therapeutic agent against cholangiocarcinoma Full article
(This article belongs to the Special Issue Novel Molecular Pathways in Oncology, 3rd Edition)
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16 pages, 6325 KiB  
Article
Echium amoenum and Rosmarinic Acid Suppress the Growth and Metastasis of Gastric Cancer AGS Cells by Promoting Apoptosis and Inhibiting EMT
by Mahdieh Ahmadi, Hong Lae Kim, So Jin Park and Hye Jin Jung
Int. J. Mol. Sci. 2024, 25(23), 12909; https://doi.org/10.3390/ijms252312909 - 30 Nov 2024
Viewed by 1183
Abstract
Gastric cancer (GC) ranks as the fifth most prevalent cancer globally. Owing to the absence of early manifest symptoms, it is difficult to diagnose GC until it has metastasized to other organs. Hence, the prevention and treatment of GC have become major concerns [...] Read more.
Gastric cancer (GC) ranks as the fifth most prevalent cancer globally. Owing to the absence of early manifest symptoms, it is difficult to diagnose GC until it has metastasized to other organs. Hence, the prevention and treatment of GC have become major concerns for patients. Echium amoenum, a traditional medicinal plant from the Boraginaceae family, exhibits various biological activities. Although recent studies have reported the anticancer properties of E. amoenum, its effects and mechanisms of action on GC cells are not yet fully understood. This study examined the anticancer effects of the ethyl acetate extract of E. amoenum (EAEC) and its main active ingredient, rosmarinic acid (RA), in GC AGS cells. EAEC and RA suppressed AGS cell growth by inducing apoptosis through caspase mediation and inhibited AGS cell metastasis by influencing the expression of crucial epithelial–mesenchymal transition (EMT) biomarkers. Furthermore, the anti-growth and anti-metastatic effects of EAEC and RA on AGS cells involved inactivation of the STAT3, AKT, and ERK1/2 pathways. Additionally, RA notably inhibited the in vivo tumor growth in AGS cells. Overall, these results indicate that EAEC and RA could serve as potential anticancer and anti-metastasis agents for GC. Full article
(This article belongs to the Special Issue Novel Molecular Pathways in Oncology, 3rd Edition)
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