Immune Mediators and Disruptors of Neural Functions
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 16812
Special Issue Editor
Interests: glial cells; immunity; neurodegeneration; multiple sclerosis; bioinformatics; data mining
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
While inflammation is considered a threat to nervous system integrity, increasing evidence indicates that a large range of immune molecules behave as mediators of neural functions. A still underestimated number of cytokines and chemokines modulate neuronal and glial functions in the normal nervous system. Similarly, increasing evidence indicates that naturally occurring autoantibodies directed against neural antigens may be involved in maintenance functions and the prevention of neurodegenerative processes. It is thus of major importance to determine if and how such immune mediators may become immune disruptors of neural functions under pathological conditions. This Special Issue is aimed at providing a global and updated view on such a duality of immune molecules, under physiological or pathological conditions. Only the crossing of knowledge and mutual feeding of distinct research fields (physiology, development, cognitive neurosciences, pathology) may allow uncovering new neuroimmune mechanisms and designing new therapeutic strategies for neurological diseases. Research works based on cellular or in vivo experimental approaches are welcome. Bioinformatics and data mining studies are acceptable, however, ad hoc systems biology methods should be applied and explored data should rely on experimental biology approaches. Pure simulation studies will not be considered.
Prof. Serge Nataf
Guest Editor
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Keywords
- glial cells
- neurons
- cytokines
- chemokines
- autoantibodies
- pathology
- physiology
- systems biology
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