Multiple Sclerosis at the Crossroads of Autoimmunity and Neurodegeneration 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 2924
Special Issue Editor
2. Stem-Cell and Brain Research Institute, 18 Avenue du Doyen Lépine, F-69500 Bron, France
3. Lyon-Est School of Medicine, University Claude Bernard Lyon 1, 43 Bd du 11 Novembre 1918, F-69100 Villeurbanne, France
Interests: multiple sclerosis pathophysiology; CNS-targeted autoimmunity; neuroinflammation; computational data mining; systems biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the continuation of our previous Special Issue, “Multiple Sclerosis at the Crossroads of Autoimmunity and Neurodegeneration”.
There is increasing evidence that the slowly evolving disability in multiple sclerosis (MS) patients is, at least in part, disconnected from relapses. Recent findings indicate that, in addition to the well-recognized progressive forms of MS, a steady aggravation of neurological deficits may also occur in patients suffering from relapsing–remitting MS. Such a clinical progression is silent (i.e., independent from both clinical relapses and brain radiological activity) and was found to be closely associated with the rate of cervical spinal cord atrophy. While neurodegeneration in MS is usually thought to result from decades-long neuroinflammatory processes, these observations indicate that autoimmunity and neurodegeneration may actually develop concurrently. This Special Issue aims to provide an updated overview of our knowledge of the links between autoimmunity and neurodegeneration in MS. All papers relating to the general topic of this Special Issue will be considered. However, we specifically encourage the submission of articles addressing one or several of the following issues in the context of MS or related disorders:
- Neuronal target antigens in MS and/or its animal model (experimental autoimmune encephalomyelitis);
- Mechanisms favoring the intrathecal persistence of autoreactive lymphocytes;
- Pro-degenerative vs. pro-regenerative impact of molecules involved in the resolution of CNS acute inflammation;
- Insights into the mechanisms of inflammation-associated axonal loss and/or synaptic pruning.
Prof. Dr. Serge Nataf
Guest Editor
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Keywords
- neurodegeneration
- multiple sclerosis
- autoimmunity
- T lymphocytes
- B lymphocytes
- demyelination
- axonal loss
- synaptic pruning
- microglia
- astrocytes
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