Special Issue "Microsatellite Instability"
A special issue of Genes (ISSN 2073-4425).
Deadline for manuscript submissions: closed (31 March 2013)
Dr. Maija Kohonen-Corish
Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia
The discovery of microsatellite instability (MSI) in colorectal tumours was one of the key breakthroughs of the early 1990’s (Aaltonen et al 1993; Thibodeau et al 1993; Ionov et al 1993) after its earlier description in the yeast and bacteria. This discovery led to the identification of defective DNA mismatch repair in many cancers and to a diagnostic test that is now part of routine patient care. The term ‘microsatellite instability’ is commonly used to describe somatic genome-wide alterations of microsatellite repeats in tissue during carcinogenesis, inflammation or aging, but includes multiple types of MSI generated by a variety of mechanisms. Of these mechanisms defective mismatch repair has been best studied, whereas the other cellular processes that generate somatic MSI are poorly understood. Apart from somatic MSI, locus-specific expansion of trinucleotide repeats that can occur during meiosis is also important for a number of diseases. This special issue seeks to cover a broad range of topics on microsatellite instability.
Dr. Maija Kohonen-Corish
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- microsatellite instability (MSI)
- mononucleotide repeat
- dinucleotide repeat
- trinucleotide repeat
- tetranucleotide repeat
- DNA repair mechanisms
- diagnostic testing
Article: Altered Ca2+ Homeostasis and Endoplasmic Reticulum Stress in Myotonic Dystrophy Type 1 Muscle Cells
Genes 2013, 4(2), 275-292; doi:10.3390/genes4020275
Received: 1 April 2013; in revised form: 3 May 2013 / Accepted: 16 May 2013 / Published: 4 June 2013| Download PDF Full-text (1030 KB) | Download XML Full-text
Last update: 12 June 2013