Special Issue "Microsatellite Instability"

Guest Editor
Dr. Maija Kohonen-Corish
Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, NSW 2010, Australia
Website: http://www.garvan.org.au/about-us/our-people/dr-maija-kohonen-corish/
E-Mail: m.corish@garvan.org.au

Dear Colleagues,

The discovery of microsatellite instability (MSI) in colorectal tumours was one of the key breakthroughs of the early 1990’s (Aaltonen et al 1993; Thibodeau et al 1993; Ionov et al 1993) after its earlier description in the yeast and bacteria. This discovery led to the identification of defective DNA mismatch repair in many cancers and to a diagnostic test that is now part of routine patient care. The term ‘microsatellite instability’ is commonly used to describe somatic genome-wide alterations of microsatellite repeats in tissue during carcinogenesis, inflammation or aging, but includes multiple types of MSI generated by a variety of mechanisms. Of these mechanisms defective mismatch repair has been best studied, whereas the other cellular processes that generate somatic MSI are poorly understood. Apart from somatic MSI, locus-specific expansion of trinucleotide repeats that can occur during meiosis is also important for a number of diseases. This special issue seeks to cover a broad range of topics on microsatellite instability.

Dr. Maija Kohonen-Corish
Guest Editor

Submission

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• microsatellite instability (MSI)
• cancer
• inflammation
• aging
• mononucleotide repeat
• dinucleotide repeat
• trinucleotide repeat
• tetranucleotide repeat
• DNA repair mechanisms
• diagnostic testing