Special Issue "Computational Studies of Immune System Function"


A special issue of Computation (ISSN 2079-3197). This special issue belongs to the section "Computational Biology".

Deadline for manuscript submissions: 30 September 2014

Special Issue Editors

Guest Editor
Dr. Filippo Castiglione
Institute for Applied Mathematics, National Research Council of Italy, Via dei Taurini 19, 00185 Rome, Italy
Website: http://www.iac.cnr.it/~filippo
E-Mail: f.castiglione@iac.cnr.it
Phone: +39 06 7716452
Fax: +39 06 7716461
Interests: computational immunology; bioinformatics; mathematical modelling; agent-based modelling; high performance computing; machine learning; pattern recognition

Guest Editor
Dr. Paolo Tieri
Institute for Applied Mathematics, National Research Council of Italy, Via dei Taurini 19, 00185 Rome, Italy
Website: http://www.iac.cnr.it/~tieri
E-Mail: p.tieri@iac.cnr.it
Phone: +39 06 49 27 09 49
Interests: network biology; systems immunology; computational immunology; bioinformatics; systems biology; data integration

Special Issue Information

Dear Colleagues,

This special issue will focus on the computational methods and models employed to study immune system functioning under health and disease conditions.

Papers discussing computational models, at any level of description (e.g., microscopic/intracellular, mesoscopic/intercellular, macroscopic/tissue or organs), along with their application in understanding the pathogenesis of specific diseases (e.g., infectious diseases, cancers, hypersensitivities, autoimmune disorders), are all welcome.

Topics of interest include, but are not limited to:

  • modeling techniques (agent vs. equation based, continuous vs. discrete, bioinformatics, network studies);
  • spatially-extended models (e.g., models of lymph channels and/or lymph nodes);
  • models of cell homing in (and trafficking among) lymph nodes;
  • computational applications to diseases, in silico testing and optimization of therapeutic/vaccination regimes;
  • models encompassing two or more spatial or temporal scales (e.g., from cell functions to organs);
  • computational methods of network analysis.

The computation aspect of these models should be posed in evidence, as it often constitutes a limiting factor (e.g., in the development of micro-simulation models). Moreover, methods addressing the issue of parameter estimation and the fast exploration of large parameter spaces, as well as the analysis of experimental data, are considered important in the field.

Research papers, reviews, and short communications on all topics related to the above issues are invited.

Dr. Filippo Castiglione
Dr. Paolo Tieri
Guest Editors


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Computation is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • computational immunology
  • immuno-informatics
  • methods in systems immunology
  • multi-scale immune models
  • immune-related disease models
  • high performance simulations
  • micro-simulation
  • models of immune cell traffic
  • methods in network analysis

Published Papers

No papers have been published in this special issue yet.

Last update: 28 March 2014

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