Computational Models of the NF-KB Signalling Pathway
AbstractIn this review article, we discuss the current state of computational modelling of the nuclear factor-kappa B (NF-ΚB) signalling pathway. NF-ΚB is a transcription factor, which is ubiquitous within cells and controls a number of immune responses, including inflammation and apoptosis. The NF-ΚB signalling pathway is tightly regulated, commencing with activation at the cell membrane, signal transduction through various components within the cytoplasm, translocation of NF-ΚB into the nucleus and, finally, the transcription of various genes relating to the innate and adaptive immune responses. There have been a number of computational (mathematical) models developed of the signalling pathway over the past decade. This review describes how these approaches have helped advance our understanding of NF-ΚB control. View Full-Text
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Williams, R.A.; Timmis, J.; Qwarnstrom, E.E. Computational Models of the NF-KB Signalling Pathway. Computation 2014, 2, 131-158.
Williams RA, Timmis J, Qwarnstrom EE. Computational Models of the NF-KB Signalling Pathway. Computation. 2014; 2(4):131-158.Chicago/Turabian Style
Williams, Richard A.; Timmis, Jon; Qwarnstrom, Eva E. 2014. "Computational Models of the NF-KB Signalling Pathway." Computation 2, no. 4: 131-158.