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Computation 2015, 3(1), 2-28; doi:10.3390/computation3010002

Computational Studies of the Intestinal Host-Microbiota Interactome

Department of Surgery, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
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Author to whom correspondence should be addressed.
Academic Editor: Filippo Castiglione
Received: 24 September 2014 / Accepted: 18 December 2014 / Published: 14 January 2015
(This article belongs to the Special Issue Computational Studies of Immune System Function)
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Abstract

A large and growing body of research implicates aberrant immune response and compositional shifts of the intestinal microbiota in the pathogenesis of many intestinal disorders. The molecular and physical interaction between the host and the microbiota, known as the host-microbiota interactome, is one of the key drivers in the pathophysiology of many of these disorders. This host-microbiota interactome is a set of dynamic and complex processes, and needs to be treated as a distinct entity and subject for study. Disentangling this complex web of interactions will require novel approaches, using a combination of data-driven bioinformatics with knowledge-driven computational modeling. This review describes the computational approaches for investigating the host-microbiota interactome, with emphasis on the human intestinal tract and innate immunity, and highlights open challenges and existing gaps in the computation methodology for advancing our knowledge about this important facet of human health. View Full-Text
Keywords: translational systems biology; translational bioinformatics; microbiome; mathematical modeling and simulation translational systems biology; translational bioinformatics; microbiome; mathematical modeling and simulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Christley, S.; Cockrell, C.; An, G. Computational Studies of the Intestinal Host-Microbiota Interactome. Computation 2015, 3, 2-28.

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