Special Issue "Aptamer Technologies"

A special issue of Chemosensors (ISSN 2227-9040).

Deadline for manuscript submissions: 30 September 2018

Special Issue Editors

Guest Editor
Dr. Mark Platt

Loughborough University, Department of Chemistry, Loughborough, United Kingdom
Website 1 | Website 2 | E-Mail
Interests: nanopore technologies; resistive pulse sensors; ion current rectification; flow chemistry; embedded sensors; flow sensors; additive manufacturing; nanoparticles; Core@Shell particles; emulsion droplet reactors; aptamers; AptaSensors; magnetic beads based assays; point of care technologies; bioassays; environmental monitoring
Guest Editor
Dr. Sourav Ghosh

Loughborough University, Loughborough, United Kingdom
Website | E-Mail
Interests: rapid/early diagnosis of infectious and chronic diseases; food, environmental and biological safety; security and monitoring; characterization, sensing and control systems in bio-manufacturing
Guest Editor
Dr. David Bunka

Aptamer Group Ltd, Suite 2.80 – 2.87, Bio Centre, Innovation Way, Heslington, York, UK
Website 1 | Website 2 | E-Mail
Interests: novel application of aptamer technologies; aptamer based diagnostics; biosensor development; aptamer based purification reagents; small molecule detection; disease stratification and monitoring; environmental monitoring

Special Issue Information

Dear Colleagues,

The continued advancement of aptamer-based technologies, and the pursuits of industry and academia to deliver new aptamers more easily, and with enhanced properties, has enriched a range of applications, such as therapeutics, bioimaging, and environmental purification and monitoring. One such area that continues to grow is that of aptamer-based sensors. The chemical versatility of synthesized aptamers allows for modified bases or amino acids to be incorporated into their secondary structures.Many sensing applications utilize chemical modifications in combination with the change in tertiary structures to create structure-switching sensors, polymerase chain reaction, and electrochemical and optical assays.

The term aptamer encompasses DNA, RNA and peptide oligomers, each subset with its own unique set of chemical properties, stabilities, and applications. In this Special Issue, we want to highlight the recent and exciting developments in the field of aptamer research. The emphasis will be on the ways that these technologies have enabled new measurements, chemical processes, and methodologies. Examples of topics will include biosensors, security, food safety, antimicrobial resistance, flow technologies, such as lateral flow and functionalized flow reactors, point of care diagnostics, and more fundamental research into the rapid identification and modification of peptides with additional properties, such as DNAzymes or enhanced affinity, to name a few.  

Dr. Mark Platt
Dr. Sourav Ghosh
Dr. David Bunka
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • AptaSensors
  • Biosensors
  • DNAzymes
  • Phage Display
  • Peptide Aptamers
  • Riboswitches
  • Food Security
  • Tagless Detection
  • Electrochemical Sensors
  • Optical Sensors
  • PCR
  • Environmental Sensors
  • Multiplexed Assay
  • Antimicrobial Resistance

Published Papers (1 paper)

View options order results:
result details:
Displaying articles 1-1
Export citation of selected articles as:

Review

Open AccessFeature PaperReview Modelling and Development of Electrical Aptasensors: A Short Review
Chemosensors 2018, 6(2), 20; https://doi.org/10.3390/chemosensors6020020
Received: 14 March 2018 / Revised: 14 April 2018 / Accepted: 25 April 2018 / Published: 27 April 2018
PDF Full-text (10311 KB) | HTML Full-text | XML Full-text
Abstract
Aptamers are strands of DNA or RNA molecules, chemically synthetized and able to bind a wide range of targets, from small molecules to live cells, and even tissues, with high affinity and specificity. Due to their efficient targeting ability, they have many different
[...] Read more.
Aptamers are strands of DNA or RNA molecules, chemically synthetized and able to bind a wide range of targets, from small molecules to live cells, and even tissues, with high affinity and specificity. Due to their efficient targeting ability, they have many different kinds of applications. Particularly attractive is their use in biotechnology and disease therapy, in substitution of antibodies. They represent a promising way for early diagnosis (aptasensors), but also for delivering imaging agents and drugs and for inhibiting specific proteins (therapeutic aptamers). Starting by briefly reviewing the most recent literature concerning advances in biomedical applications of aptamers and aptasensors, the focus is on the issues of a theoretical/computational framework (proteotronics) for modelling the electrical properties of biomolecules. Some recent results of proteotronics concerning the electrical, topological and affinity properties of aptamers are reviewed. Full article
(This article belongs to the Special Issue Aptamer Technologies)
Figures

Graphical abstract

Back to Top