Special Issue "Palladium Catalysts for Cross-Coupling Reaction"
A special issue of Catalysts (ISSN 2073-4344).
Deadline for manuscript submissions: 15 August 2013
Prof. Dr. Kei Manabe
University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan
Interests: cross coupling; palladium catalyst; homogeneous/heterogeneous catalyst; selective reaction; allylic substitution; carbonylation; C-H activation; reaction mechanism; organometallic chemistry
Palladium is definitely one of the most important transition metals in organic synthesis. The significance of palladium catalysts is evident by the fact that the Nobel Prize in Chemistry 2010 was awarded to Richard F. Heck, Ei-ichi Negishi, and Akira Suzuki “for palladium-catalyzed cross couplings in organic synthesis”. Though the cross coupling chemistry emerged during the 1970s, this research field is still evolving and considerable attention is being given to investigate new catalytic reactions such as stereo- and site-selective cross coupling, reactions with less reactive leaving groups, and cross coupling at C-H positions. This special issue will cover significant development in the exciting field of palladium-catalyzed cross coupling.
Prof. Dr. Kei Manabe
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- cross coupling
- palladium catalyst
- homogeneous/heterogeneous catalyst
- selective reaction
- allylic substitution
- C-H activation
- reaction mechanism
- organometallic chemistry
Article: Mechanistic Studies for Synthesis of Bis(indolyl)methanes: Pd-Catalyzed C–H Activation of Indole–Carboxylic Acids with Benzyl Alcohols in Water
Catalysts 2013, 3(2), 486-500; doi:10.3390/catal3020486
Received: 27 March 2013; in revised form: 9 May 2013 / Accepted: 10 May 2013 / Published: 16 May 2013| Download PDF Full-text (408 KB) | Download XML Full-text |
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Palladium-Catalyzed Synthesis of Pentafluorophenyl-Substituted Porphyins
Author: Toshikatsu Takanami Affiliation, Meiji Pharmaceutical University, Japan
Abstract: An efficient direct introduction of perfluoroaromatic substituents, such as pentafluorophenyl group, to porphyrin core utilizing palladium-catalyzed cross-coupling reaction of brominated porphyrins with bis(penta¬ fluoro¬ phenyl)¬zinc will be described in the planning paper. It is well-known that the chemical, physical, and biological properties of porphyrins can be systematically regulated by the electronic, steric, and conformational environments of their peripheral substituents as well as the central metal ions. Pentafluorophenyl and related perfluoroaromatic groups are expected to greatly affect the electronic properties of porphyrin core. Only a few methods, however, have been available for the preparation of porphyrins bearing perfluoroaromatic groups. Most popular and classic approach to these fluorinated porphyrins involves multiple condensation reactions of the appropriate aldehyde(s) with various monopyrroles or substituted dipyrromethanes under acidic conditions, followed by oxidation of resulting porphyrinogen intermediates. Despite significant improvements with the introduction of new reaction conditions, these multiple condensation methods still suffer from low yields, significant side products, and tedious purification, thereby restraining efficient preparation of porphyrin derivatives bearing perfluoroaromatic groups. Thus, the development of an alternative approach to porphyrins bearing perfluoroaromatic groups with higher simplicity, generality, and practicality remains an important goal. To achieve this goal, we have developed a palladium-catalyzed coupling reaction of brominated porphyrins with bis(perfluorophenyl)Zn reagents, the method being a new and straightforward access to porphyrin derivatives bearing perfluoroaromatic groups. The details of these approaches we have developed will be described in the planning paper.
Last update: 23 April 2013