Catalysts 2013, 3(4), 794-810; doi:10.3390/catal3040794
Review

Palladium-Catalyzed Intermolecular Oxidative Amination of Alkenes with Amines, Using Molecular Oxygen as Terminal Oxidant

Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564-8680, Japan
* Author to whom correspondence should be addressed.
Received: 25 July 2013; in revised form: 29 September 2013 / Accepted: 8 October 2013 / Published: 16 October 2013
(This article belongs to the Special Issue Palladium Catalysts for Cross-Coupling Reaction)
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Abstract: In this review, we summarize recent progress from our group with regard to Pd-catalyzed oxidative amination of alkenes with amines. Intermolecular oxidative amination of alkenes with secondary anilines was induced using a palladium-complex catalyst combined with molybdovanadophosphate as a co-catalyst under dioxygen, leading to allylic amines and enamines in good yields with high selectivities. The reaction proceeded efficiently, using molecular oxygen as the terminal oxidant. In addition, palladium-catalyzed oxidative amination of alkenes with anilines as primary amines was achieved using molecular oxygen as the sole oxidant, producing (Z)-N-alkenyl-substituted anilines in high yields.
Keywords: amination; enamine; allylic amine; molybdovanadophosphate; oxidative coupling; alkenes

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MDPI and ACS Style

Obora, Y.; Ishii, Y. Palladium-Catalyzed Intermolecular Oxidative Amination of Alkenes with Amines, Using Molecular Oxygen as Terminal Oxidant. Catalysts 2013, 3, 794-810.

AMA Style

Obora Y, Ishii Y. Palladium-Catalyzed Intermolecular Oxidative Amination of Alkenes with Amines, Using Molecular Oxygen as Terminal Oxidant. Catalysts. 2013; 3(4):794-810.

Chicago/Turabian Style

Obora, Yasushi; Ishii, Yasutaka. 2013. "Palladium-Catalyzed Intermolecular Oxidative Amination of Alkenes with Amines, Using Molecular Oxygen as Terminal Oxidant." Catalysts 3, no. 4: 794-810.

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