Special Issue "Surgery Induced Tumorigenesis in Breast and Other Cancers: An Inconvenient Truth?"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (30 November 2010)
Dr. Michael W. Retsky
Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Phone: +1 203 675 0017
Interests: cancer research; electron beam technology
Bimodal relapse patterns in early stage breast cancer are observed in multiple databases. This is unexplainable with the long-accepted continuous growth model. In order to explain these data, it was proposed with the aid of computer simulations that micrometastatic tumor growth includes periods of temporary dormancy and furthermore, surgery to remove primary tumors kick-starts growth of dormant distant disease. Apparently over half of all relapses are accelerated by such means. Two previously unreported modes of relapse were proposed as the dominant paths leading to treatment failure in early stage breast cancer. Single dormant cells are induced into division by surgery, an effect that increases with primary size. Also angiogenesis is induced in dormant avascular micrometastases mainly for premenopausal patients with positive lymph nodes. This theory may provide new explanations for a wide variety of clinical breast cancer features that were previously thought to be unconnected. In addition to the relapse patterns, this is proposed to at least partly explain paradoxical mammography data for women age 40-49, that the benefit of adjuvant chemotherapy is most effective by far for premenopausal node positive patients, breast cancer in young women is often labeled “aggressive”, the overall heterogeneous nature of breast cancer, and the racial disparity in outcome. To present a forum for focused discussion, this special issue of Cancers will be devoted to papers that argue for and against this new theory.
Dr. Michael W. Retsky
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 500 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- breast cancer
- distant relapse
- adjuvant chemotherapy
- racial disparities in outcome
- bimodal relapse pattern
Review: Surgery Triggers Outgrowth of Latent Distant Disease in Breast Cancer: An Inconvenient Truth?
Cancers 2010, 2(2), 305-337; doi:10.3390/cancers2020305
Received: 9 March 2010; in revised form: 25 March 2010 / Accepted: 26 March 2010 / Published: 30 March 2010| Download PDF Full-text (343 KB)
Review: Surgery as a Double-Edged Sword: A Clinically Feasible Approach to Overcome the Metastasis-Promoting Effects of Surgery by Blunting Stress and Prostaglandin Responses
Cancers 2010, 2(4), 1929-1951; doi:10.3390/cancers2041929
Received: 13 October 2010; in revised form: 14 November 2010 / Accepted: 23 November 2010 / Published: 24 November 2010| Download PDF Full-text (182 KB)
Cancers 2011, 3(1), 252-266; doi:10.3390/cancers3010252
Received: 15 December 2010; in revised form: 3 January 2011 / Accepted: 6 January 2011 / Published: 11 January 2011| Download PDF Full-text (141 KB) | Download XML Full-text
Review: Why Victory in the War on Cancer Remains Elusive: Biomedical Hypotheses and Mathematical Models
Cancers 2011, 3(1), 340-367; doi:10.3390/cancers3010340
Received: 3 December 2010; in revised form: 6 January 2011 / Accepted: 11 January 2011 / Published: 17 January 2011| Download PDF Full-text (249 KB) | Download XML Full-text
Cancers 2011, 3(1), 730-746; doi:10.3390/cancers3010730
Received: 20 December 2010; in revised form: 28 January 2011 / Accepted: 11 February 2011 / Published: 21 February 2011| Download PDF Full-text (185 KB) | Download XML Full-text
Review: An Evolutionary Explanation for the Perturbation of the Dynamics of Metastatic Tumors Induced by Surgery and Acute Inflammation
Cancers 2011, 3(1), 945-970; doi:10.3390/cancers3010945
Received: 4 January 2011; in revised form: 17 February 2011 / Accepted: 22 February 2011 / Published: 2 March 2011| Download PDF Full-text (776 KB) | Download XML Full-text
Cancers 2011, 3(2), 2540-2553; doi:10.3390/cancers3022540
Received: 1 April 2011; in revised form: 23 May 2011 / Accepted: 26 May 2011 / Published: 8 June 2011| Download PDF Full-text (317 KB) | Download XML Full-text
Cancers 2011, 3(3), 2844-2857; doi:10.3390/cancers3032844
Received: 30 March 2011; in revised form: 2 June 2011 / Accepted: 27 June 2011 / Published: 6 July 2011| Download PDF Full-text (128 KB) | Download XML Full-text
Cancers 2012, 4(1), 156-164; doi:10.3390/cancers4010156
Received: 26 December 2011; in revised form: 12 February 2012 / Accepted: 14 February 2012 / Published: 20 February 2012| Download PDF Full-text (285 KB) | Download XML Full-text
Last update: 25 September 2012