Special Issue "Surgery Induced Tumorigenesis in Breast and Other Cancers: An Inconvenient Truth?"

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A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (30 November 2010)

Special Issue Editor

Guest Editor
Dr. Michael W. Retsky
Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Website: http://connects.catalyst.harvard.edu/PROFILES/ProfileDetails.aspx?Person=MWR2
E-Mail: michael.retsky@gmail.com
Phone: +1 203 675 0017
Interests: cancer research; electron beam technology

Special Issue Information

Dear Colleagues,

Bimodal relapse patterns in early stage breast cancer are observed in multiple databases. This is unexplainable with the long-accepted continuous growth model. In order to explain these data, it was proposed with the aid of computer simulations that micrometastatic tumor growth includes periods of temporary dormancy and furthermore, surgery to remove primary tumors kick-starts growth of dormant distant disease. Apparently over half of all relapses are accelerated by such means. Two previously unreported modes of relapse were proposed as the dominant paths leading to treatment failure in early stage breast cancer. Single dormant cells are induced into division by surgery, an effect that increases with primary size. Also angiogenesis is induced in dormant avascular micrometastases mainly for premenopausal patients with positive lymph nodes. This theory may provide new explanations for a wide variety of clinical breast cancer features that were previously thought to be unconnected. In addition to the relapse patterns, this is proposed to at least partly explain paradoxical mammography data for women age 40-49, that the benefit of adjuvant chemotherapy is most effective by far for premenopausal node positive patients, breast cancer in young women is often labeled “aggressive”, the overall heterogeneous nature of breast cancer, and the racial disparity in outcome. To present a forum for focused discussion, this special issue of Cancers will be devoted to papers that argue for and against this new theory.

Dr. Michael W. Retsky
Guest Editor

Keywords

  • breast cancer
  • dormancy
  • angiogenesis
  • distant relapse
  • mammography
  • adjuvant chemotherapy
  • racial disparities in outcome
  • heterogeneity
  • aggressiveness
  • bimodal relapse pattern
  • surgery

Published Papers (9 papers)

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Displaying article 1-9
p. 156-164
by ,  and
Cancers 2012, 4(1), 156-164; doi:10.3390/cancers4010156
Received: 26 December 2011; in revised form: 12 February 2012 / Accepted: 14 February 2012 / Published: 20 February 2012
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p. 2844-2857
by  and
Cancers 2011, 3(3), 2844-2857; doi:10.3390/cancers3032844
Received: 30 March 2011; in revised form: 2 June 2011 / Accepted: 27 June 2011 / Published: 6 July 2011
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p. 2540-2553
by
Cancers 2011, 3(2), 2540-2553; doi:10.3390/cancers3022540
Received: 1 April 2011; in revised form: 23 May 2011 / Accepted: 26 May 2011 / Published: 8 June 2011
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p. 945-970
by
Cancers 2011, 3(1), 945-970; doi:10.3390/cancers3010945
Received: 4 January 2011; in revised form: 17 February 2011 / Accepted: 22 February 2011 / Published: 2 March 2011
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p. 730-746
by ,  and
Cancers 2011, 3(1), 730-746; doi:10.3390/cancers3010730
Received: 20 December 2010; in revised form: 28 January 2011 / Accepted: 11 February 2011 / Published: 21 February 2011
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p. 340-367
by
Cancers 2011, 3(1), 340-367; doi:10.3390/cancers3010340
Received: 3 December 2010; in revised form: 6 January 2011 / Accepted: 11 January 2011 / Published: 17 January 2011
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p. 252-266
by
Cancers 2011, 3(1), 252-266; doi:10.3390/cancers3010252
Received: 15 December 2010; in revised form: 3 January 2011 / Accepted: 6 January 2011 / Published: 11 January 2011
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p. 1929-1951
by  and
Cancers 2010, 2(4), 1929-1951; doi:10.3390/cancers2041929
Received: 13 October 2010; in revised form: 14 November 2010 / Accepted: 23 November 2010 / Published: 24 November 2010
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p. 305-337
by , , ,  and
Cancers 2010, 2(2), 305-337; doi:10.3390/cancers2020305
Received: 9 March 2010; in revised form: 25 March 2010 / Accepted: 26 March 2010 / Published: 30 March 2010
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Last update: 25 February 2014

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