Cancers 2012, 4(1), 156-164; doi:10.3390/cancers4010156
Article

Does Secondary Inflammatory Breast Cancer Represent Post-Surgical Metastatic Disease?

Received: 26 December 2011; in revised form: 12 February 2012 / Accepted: 14 February 2012 / Published: 20 February 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The phenomenon of accelerated tumor growth following surgery has been observed repeatedly and merits further study. Inflammatory breast carcinoma (IBC) is widely recognized as an extremely aggressive malignancy characterized by micrometastasis at the time of diagnosis, with one interesting subgroup defined as secondary IBC where pathologically identifiable IBC appears after surgical treatment of a primary non-inflammatory breast cancer. One possible mechanism can be related to the stimulation of dormant micrometastasis through local angiogenesis occurring as part of posttraumatic healing. In this report, we review cases of secondary IBC and others where localized trauma was followed by the appearance of IBC at the traumatized site that have been identified by our IBC Registry (IBCR) and hypothesize that angiogenesis appearing as part of the healing process could act as an accelerant to an otherwise latent breast malignancy. It is therefore possible that secondary IBC can be used as a model to support local angiogenesis as an important contributor to the development of an aggressive cancer.
Keywords: surgery; inflammatory breast cancer; trauma; secondary IBC; dormant micrometastasis; IBC registry; angiogenesis
PDF Full-text Download PDF Full-Text [285 KB, uploaded 20 February 2012 10:34 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Hashmi, S.; Zolfaghari, L.; Levine, P.H. Does Secondary Inflammatory Breast Cancer Represent Post-Surgical Metastatic Disease? Cancers 2012, 4, 156-164.

AMA Style

Hashmi S, Zolfaghari L, Levine PH. Does Secondary Inflammatory Breast Cancer Represent Post-Surgical Metastatic Disease? Cancers. 2012; 4(1):156-164.

Chicago/Turabian Style

Hashmi, Salman; Zolfaghari, Ladan; Levine, Paul H. 2012. "Does Secondary Inflammatory Breast Cancer Represent Post-Surgical Metastatic Disease?" Cancers 4, no. 1: 156-164.

Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert