Special Issue "Prognostic and Predictive Factors in Colorectal Cancer"

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A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (28 February 2011)

Special Issue Editor

Guest Editor
Dr. Alessandro Lugli
Deputy Chief Pathologist, Head, Division of Clinical Pathology, Institute of Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland
E-Mail: alessandro.lugli@pathology.unibe.ch
Phone: +41 31 632 99 58
Fax: +41 31 632 49 95
Interests: gastrointestinal and liver tumors; tumor diagnosis and staging; prognostic and predictive biomarkers

Special Issue Information

Dear Colleagues,

Colorectal cancer (CRC) is one of the most common malignant diseases worldwide. Based on the chromosomal instability (CIN) and serrated pathways, CRC can be subdivided into mismatch-repair proficient (85%) and deficient (15%) tumors. In 2007, Jeremy Jass proposed a new molecular classification of CRC including KRAS, BRAF, mismatch-repair, CpG Island Methylator Phenotype (CIMP) and O-6-methylguanine-DNA methyltransferase (MGMT) status. According to the UICC/AJCC tumor extent, lymph node and distant metastasis, lymphatic and vascular invasion are considered the essential prognostic factors. Although several recent studies have proposed different histomorphological, immunohistochemical and molecular biomarkers to improve stratification of CRC patients into prognostic subgroups, there are no officially established additional prognostic and predictive factors included in the pre- and postoperative management of non-metastatic CRC. Due to the implementation of anti-EGFR therapy for metastatic CRC patients in the last years, predictive factors such as the KRAS mutational status are now included in the therapeutic assessment. This special issue of Cancers will include original contributions or review articles that focus on the prognostic and predictive value of molecular, immunohistochemical and histomorphological biomarkers to help improve the clinical management of CRC patients.

Dr. Alessandro Lugli
Guest Editor

Keywords

  • TNM classification
  • prognostic factors
  • predictive factors
  • KRAS
  • BRAF
  • CIMP
  • MGMT
  • mismatch repair status
  • molecular biomarkers
  • immunohistochemistry
  • histomorphological factors

Published Papers (12 papers)

Cancers 2011, 3(3), 2858-2869; doi:10.3390/cancers3032858
Received: 10 May 2011; in revised form: 23 June 2011 / Accepted: 27 June 2011 / Published: 7 July 2011
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Cancers 2011, 3(2), 2767-2810; doi:10.3390/cancers3022767
Received: 10 March 2011; in revised form: 14 June 2011 / Accepted: 15 June 2011 / Published: 23 June 2011
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Cancers 2011, 3(2), 2302-2315; doi:10.3390/cancers3022302
Received: 25 January 2011; in revised form: 22 April 2011 / Accepted: 4 May 2011 / Published: 11 May 2011
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Cancers 2011, 3(2), 2176-2194; doi:10.3390/cancers3022176
Received: 11 March 2011; in revised form: 8 April 2011 / Accepted: 11 April 2011 / Published: 26 April 2011
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Cancers 2011, 3(2), 2160-2168; doi:10.3390/cancers3022160
Received: 23 February 2011; in revised form: 5 April 2011 / Accepted: 6 April 2011 / Published: 26 April 2011
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Cancers 2011, 3(2), 2080-2105; doi:10.3390/cancers3022080
Received: 18 February 2011; in revised form: 21 March 2011 / Accepted: 23 March 2011 / Published: 19 April 2011
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Cancers 2011, 3(2), 1844-1860; doi:10.3390/cancers3021844
Received: 27 February 2011; Accepted: 25 March 2011 / Published: 1 April 2011
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Cancers 2011, 3(2), 1708-1731; doi:10.3390/cancers3021708
Received: 4 February 2010; in revised form: 13 March 2011 / Accepted: 21 March 2011 / Published: 29 March 2011
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abstract graphic

Cancers 2011, 3(2), 1622-1638; doi:10.3390/cancers3021622
Received: 23 January 2011; in revised form: 13 March 2011 / Accepted: 18 March 2011 / Published: 29 March 2011
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Cancers 2011, 3(1), 1274-1284; doi:10.3390/cancers3011274
Received: 19 January 2011; in revised form: 28 February 2011 / Accepted: 4 March 2011 / Published: 11 March 2011
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Cancers 2011, 3(1), 91-105; doi:10.3390/cancers3010091
Received: 24 October 2010; in revised form: 7 December 2010 / Accepted: 20 December 2010 / Published: 29 December 2010
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Cancers 2010, 2(3), 1405-1418; doi:10.3390/cancers2031405
Received: 24 May 2010; in revised form: 23 June 2010 / Accepted: 25 June 2010 / Published: 28 June 2010
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Last update: 25 February 2014

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