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Cancers 2011, 3(2), 1844-1860; doi:10.3390/cancers3021844

Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into Practice

Sarah Cannon Research Institute, 93 Harley Street, W1G 6AD, London, UK
Author to whom correspondence should be addressed.
Received: 27 February 2011 / Accepted: 25 March 2011 / Published: 1 April 2011
(This article belongs to the Special Issue Prognostic and Predictive Factors in Colorectal Cancer)
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The growing number of therapeutic agents and known molecular targets in oncology makes the study and clinical use of biomarkers imperative for improving response and survival, reducing toxicity and ensuring economic sustainability. Colorectal cancer, among others, is at the forefront of development of predictive and prognostic biomarkers; however, the difficulty lies in translating potential biomarkers garnered from retrospective analyses in small numbers of patients to generalizable and affordable biomarkers used worldwide. This review outlines the progress made in prognostic and predictive biomarkers in advanced colorectal cancer (ACRC) from the early use of carcinoembryonic antigen (CEA) to the KRAS mutation and beyond. Future challenges are to incorporate standardized and validated methods preferentially during early phases of drug development linked with sophisticated biostatistical support. New trial designs focusing on biomarkers will be essential not only for better understanding of mechanisms of action, but also to make confident ‘go or no-go’ decisions. View Full-Text
Keywords: prognostic biomarker; predictive biomarker; colorectal cancer; kras mutation prognostic biomarker; predictive biomarker; colorectal cancer; kras mutation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lemech, C.; Arkenau, H.-T. Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into Practice. Cancers 2011, 3, 1844-1860.

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