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Cancers 2011, 3(2), 1622-1638; doi:10.3390/cancers3021622
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Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach

* , ,  and
Received: 23 January 2011; in revised form: 13 March 2011 / Accepted: 18 March 2011 / Published: 29 March 2011
(This article belongs to the Special Issue Prognostic and Predictive Factors in Colorectal Cancer)
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Abstract: It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathological staging. The potential predictive and prognostic biomarkers which have stemmed from the study of the genetic basis of colorectal cancer and therapeutics are discussed with a focus on mismatch repair status, KRAS, BRAF, 18qLOH, CIMP and TGF-β.
Keywords: predictive and prognostic factors; colorectal cancer; personalized medicine; APC; MSI; MMR; KRAS; BRAF; 18qLOH; CIMP; TGF-β; CIN; MGMT; TP53; FOBT; vimentin; circulating tumor cells predictive and prognostic factors; colorectal cancer; personalized medicine; APC; MSI; MMR; KRAS; BRAF; 18qLOH; CIMP; TGF-β; CIN; MGMT; TP53; FOBT; vimentin; circulating tumor cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kulendran, M.; Stebbing, J.F.; Marks, C.G.; Rockall, T.A. Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach. Cancers 2011, 3, 1622-1638.

AMA Style

Kulendran M, Stebbing JF, Marks CG, Rockall TA. Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach. Cancers. 2011; 3(2):1622-1638.

Chicago/Turabian Style

Kulendran, Myutan; Stebbing, John F.; Marks, Christopher G.; Rockall, Timothy A. 2011. "Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach." Cancers 3, no. 2: 1622-1638.


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