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Cancers 2011, 3(2), 1622-1638; doi:10.3390/cancers3021622

Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach

Department of Coloproctology, Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, Guildford, UK
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Received: 23 January 2011 / Revised: 13 March 2011 / Accepted: 18 March 2011 / Published: 29 March 2011
(This article belongs to the Special Issue Prognostic and Predictive Factors in Colorectal Cancer)
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Abstract

It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathological staging. The potential predictive and prognostic biomarkers which have stemmed from the study of the genetic basis of colorectal cancer and therapeutics are discussed with a focus on mismatch repair status, KRAS, BRAF, 18qLOH, CIMP and TGF-β. View Full-Text
Keywords: predictive and prognostic factors; colorectal cancer; personalized medicine; APC; MSI; MMR; KRAS; BRAF; 18qLOH; CIMP; TGF-β; CIN; MGMT; TP53; FOBT; vimentin; circulating tumor cells predictive and prognostic factors; colorectal cancer; personalized medicine; APC; MSI; MMR; KRAS; BRAF; 18qLOH; CIMP; TGF-β; CIN; MGMT; TP53; FOBT; vimentin; circulating tumor cells
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kulendran, M.; Stebbing, J.F.; Marks, C.G.; Rockall, T.A. Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach. Cancers 2011, 3, 1622-1638.

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