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• Kulendran, M
• Stebbing, J
• Marks, C
• Rockall, T
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• Kulendran, M
• Stebbing, J
• Marks, C
• Rockall, T
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• Kulendran, M
• Stebbing, J
• Marks, C
• Rockall, T

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Cancers 2011, 3(2), 1622-1638; doi:10.3390/cancers3021622

Review

Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach

Myutan Kulendran* , John F. Stebbing, Christopher G. Marks and Timothy A. Rockall

Department of Coloproctology, Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, Guildford, UK

* Author to whom correspondence should be addressed.

Received: 23 January 2011; in revised form: 13 March 2011 / Accepted: 18 March 2011 / Published: 29 March 2011

(This article belongs to the Special Issue Prognostic and Predictive Factors in Colorectal Cancer)

Download PDF Full-Text [396 KB, uploaded 29 March 2011 09:31 CEST]

Abstract: It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathological staging. The potential predictive and prognostic biomarkers which have stemmed from the study of the genetic basis of colorectal cancer and therapeutics are discussed with a focus on mismatch repair status, KRAS, BRAF, 18qLOH, CIMP and TGF-β.

Keywords: predictive and prognostic factors; colorectal cancer; personalized medicine; APC; MSI; MMR; KRAS; BRAF; 18qLOH; CIMP; TGF-β; CIN; MGMT; TP53; FOBT; vimentin; circulating tumor cells

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