Cancers 2011, 3(2), 2080-2105; doi:10.3390/cancers3022080
Review

Prognostic Value of Colorectal Cancer Biomarkers

1email, 1,2email, 2email and 2,3,* email
Received: 18 February 2011; in revised form: 21 March 2011 / Accepted: 23 March 2011 / Published: 19 April 2011
(This article belongs to the Special Issue Prognostic and Predictive Factors in Colorectal Cancer)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Despite the large amount of data in cancer biology and many studies into the likely survival of colorectal cancer (CRC) patients, knowledge regarding the issue of CRC prognostic biomarkers remains poor. The Tumor-Node-Metastasis (TNM) staging system continues to be the most powerful and reliable predictor of the clinical outcome of CRC patients. The exponential increase of knowledge in the field of molecular genetics has lead to the identification of specific alterations involved in the malignant progression. Many of these genetic alterations were proposed as biomarkers which could be used in clinical practice to estimate CRC prognosis. Recently there has been an explosive increase in the number of putative biomarkers able to predict the response to specific adjuvant treatment. In this review we explore and summarize data concerning prognostic and predictive biomarkers and we attempt to shed light on recent research that could lead to the emergence of new biomarkers in CRC.
Keywords: colorectal cancer; prognostic biomarkers; predictive biomarkers
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MDPI and ACS Style

Bianchi, P.; Laghi, L.; Delconte, G.; Malesci, A. Prognostic Value of Colorectal Cancer Biomarkers. Cancers 2011, 3, 2080-2105.

AMA Style

Bianchi P, Laghi L, Delconte G, Malesci A. Prognostic Value of Colorectal Cancer Biomarkers. Cancers. 2011; 3(2):2080-2105.

Chicago/Turabian Style

Bianchi, Paolo; Laghi, Luigi; Delconte, Gabriele; Malesci, Alberto. 2011. "Prognostic Value of Colorectal Cancer Biomarkers." Cancers 3, no. 2: 2080-2105.

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