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Biomarkers in Advanced Colorectal Cancer: Challenges in Translating Clinical Research into Practice
Cancers 2011, 3(2), 2080-2105; doi:10.3390/cancers3022080

Prognostic Value of Colorectal Cancer Biomarkers

1 Laboratory of Molecular Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milano 20089, Italy 2 Department of Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milano 20089, Italy 3 Department of Translational Medicine, University of Milan, Milano 20089, Italy
* Author to whom correspondence should be addressed.
Received: 18 February 2011 / Revised: 21 March 2011 / Accepted: 23 March 2011 / Published: 19 April 2011
(This article belongs to the Special Issue Prognostic and Predictive Factors in Colorectal Cancer)
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Despite the large amount of data in cancer biology and many studies into the likely survival of colorectal cancer (CRC) patients, knowledge regarding the issue of CRC prognostic biomarkers remains poor. The Tumor-Node-Metastasis (TNM) staging system continues to be the most powerful and reliable predictor of the clinical outcome of CRC patients. The exponential increase of knowledge in the field of molecular genetics has lead to the identification of specific alterations involved in the malignant progression. Many of these genetic alterations were proposed as biomarkers which could be used in clinical practice to estimate CRC prognosis. Recently there has been an explosive increase in the number of putative biomarkers able to predict the response to specific adjuvant treatment. In this review we explore and summarize data concerning prognostic and predictive biomarkers and we attempt to shed light on recent research that could lead to the emergence of new biomarkers in CRC.
Keywords: colorectal cancer; prognostic biomarkers; predictive biomarkers colorectal cancer; prognostic biomarkers; predictive biomarkers
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Bianchi, P.; Laghi, L.; Delconte, G.; Malesci, A. Prognostic Value of Colorectal Cancer Biomarkers. Cancers 2011, 3, 2080-2105.

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