Special Issue "Circulating Tumor Cells in Cancers"

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A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (31 August 2013)

Special Issue Editors

Guest Editor
Prof. Dr. Klaus Pantel
Department of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Website: http://www.uke.uni-hamburg.de/institute/tumorbiologie/
E-Mail: tumorbiologie@uke.uni-hamburg.de
Phone: +49 (0)40 7410 53503
Fax: +49 (0)40 7410 55379
Interests: solid tumors; circulating tumor cells; micrometastasis; cancer dormancy; liquid biopsy; companion diagnostics; biomarkers

Guest Editor
Dr. Catherine Alix-Panabières
IRB, Laboratoire Cellules Circulantes Rares Humaines, MCU-PH, CHU Montpellier,Université Montpellier 1, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
E-Mail: c-panabieres@chu-montpellier.fr
Phone: +33 4 67 33 05 05
Fax: +33 4 67 33 01 13
Interests: solid tumors; circulating tumor cells; micrometastasis; cancer dormancy; liquid biopsy; companion diagnostics; biomarkers

Special Issue Information

Dear Colleagues,

This issue invites experts to contribute original research reports as well as review articles that describe studies on circulating tumor cells (CTC). Solid tumors derived from epithelial tissues (i.e., carcinomas) are responsible for 90% of all new cancers in Europe, including breast, prostate, lung and colorectal cancer. Present tumor staging is mainly based on local tumor extension, metastatic lymph node involvement and evidence of overt distant metastasis obtained by imaging technologies. However, these staging procedures are not sensitive enough to detect minute amounts of metastatic cells. Many teams have focused on the development of sensitive assays that allow the specific detection of single tumor cells in the blood of cancer patients. These methods allow the detection and characterization of early metastatic spread, provide unique insights into the biology of metastatic progression of human tumors and support the use of CTC blood tests as companion diagnostics and “liquid biopsy” in the context of therapeutic interventions.

Potential topics include, but are not limited to:

  • Development of new technologies for isolation & detection of CTC
  • Development of new approaches to characterize CTC at the molecular level
  • Biology of CTC with a focus on cancer stem cell or cancer-initiating tumor cells, epithelial-to-mesenchymal (EMT) plasticity & cancer dormancy
  • Clinical studies in different cancer types (i.e., breast, prostate, colon, lung, head & neck, melanoma, bladder cancer..) with emphasis on CTC as prognostic and predictive marker and as real-time liquid to unravel the dynamic changes in CTC during therapy (e.g., therapeutic targets and drug resistance pathways).

Prof. Klaus Pantel
Dr. Catherine Alix-Panabières
Guest Editors

Keywords

  • CTC isolation & specific detection
  • CTC molecular characterization
  • CTC and EMT-plasticity
  • CTC and cancer stem cells
  • DTC/CTC as indicators of cancer dormancy
  • Clinical relevance of CTC (prognostic, predictive biomarker)
  • CTC as companion diagnostics in clinical trials testing new drugs
  • CTC as real time liquid biopsy of metastatic cells
  • Published Papers (15 papers)

    by  and
    Cancers 2014, 6(2), 1195-1207; doi:10.3390/cancers6021195
    Received: 13 March 2014; in revised form: 22 April 2014 / Accepted: 22 May 2014 / Published: 28 May 2014
    Show/Hide Abstract | PDF Full-text (133 KB) | HTML Full-text | XML Full-text

    by , , , ,  and
    Cancers 2014, 6(2), 684-707; doi:10.3390/cancers6020684
    Received: 10 September 2013; in revised form: 24 October 2013 / Accepted: 10 March 2014 / Published: 25 March 2014
    Show/Hide Abstract | Cited by 1 | PDF Full-text (711 KB) | HTML Full-text | XML Full-text

    by  and
    Cancers 2014, 6(1), 595-624; doi:10.3390/cancers6010595
    Received: 2 September 2013; in revised form: 28 January 2014 / Accepted: 20 February 2014 / Published: 13 March 2014
    Show/Hide Abstract | Cited by 1 | PDF Full-text (1031 KB) | HTML Full-text | XML Full-text

    by  and
    Cancers 2014, 6(1), 545-579; doi:10.3390/cancers6010545
    Received: 18 October 2013; in revised form: 12 February 2014 / Accepted: 20 February 2014 / Published: 12 March 2014
    Show/Hide Abstract | PDF Full-text (1396 KB) | HTML Full-text | XML Full-text

    by , , , , , ,  and
    Cancers 2014, 6(1), 323-332; doi:10.3390/cancers6010323
    Received: 24 October 2013; in revised form: 8 January 2014 / Accepted: 9 January 2014 / Published: 7 February 2014
    Show/Hide Abstract | PDF Full-text (593 KB) | HTML Full-text | XML Full-text

    by , , , , , , , , ,  and
    Cancers 2014, 6(1), 153-165; doi:10.3390/cancers6010153
    Received: 15 August 2013; in revised form: 11 November 2013 / Accepted: 9 January 2014 / Published: 21 January 2014
    Show/Hide Abstract | Cited by 1 | PDF Full-text (501 KB) | HTML Full-text | XML Full-text

    by ,  and
    Cancers 2014, 6(1), 143-152; doi:10.3390/cancers6010143
    Received: 11 September 2013; in revised form: 1 October 2013 / Accepted: 9 January 2014 / Published: 15 January 2014
    Show/Hide Abstract | PDF Full-text (184 KB) | HTML Full-text | XML Full-text

    by , , , ,  and
    Cancers 2014, 6(1), 128-142; doi:10.3390/cancers6010128
    Received: 25 November 2013; in revised form: 25 November 2013 / Accepted: 7 January 2014 / Published: 15 January 2014
    Show/Hide Abstract | Cited by 1 | PDF Full-text (966 KB) | HTML Full-text | XML Full-text

    by
    Cancers 2013, 5(4), 1739-1747; doi:10.3390/cancers5041739
    Received: 11 September 2013; in revised form: 12 October 2013 / Accepted: 5 November 2013 / Published: 13 December 2013
    Show/Hide Abstract | Cited by 1 | PDF Full-text (310 KB) | HTML Full-text | XML Full-text

    by  and
    Cancers 2013, 5(4), 1691-1738; doi:10.3390/cancers5041691
    Received: 9 September 2013; in revised form: 17 November 2013 / Accepted: 19 November 2013 / Published: 10 December 2013
    Show/Hide Abstract | Cited by 1 | PDF Full-text (3826 KB) | HTML Full-text | XML Full-text | Supplementary Files

    by ,  and
    Cancers 2013, 5(4), 1676-1690; doi:10.3390/cancers5041676
    Received: 25 September 2013; in revised form: 20 November 2013 / Accepted: 25 November 2013 / Published: 4 December 2013
    Show/Hide Abstract | Cited by 2 | PDF Full-text (589 KB) | HTML Full-text | XML Full-text

    by  and
    Cancers 2013, 5(4), 1619-1642; doi:10.3390/cancers5041619
    Received: 4 September 2013; in revised form: 3 October 2013 / Accepted: 22 October 2013 / Published: 4 December 2013
    Show/Hide Abstract | Cited by 2 | PDF Full-text (1827 KB) | HTML Full-text | XML Full-text

    by  and
    Cancers 2013, 5(4), 1545-1565; doi:10.3390/cancers5041545
    Received: 2 September 2013; in revised form: 8 October 2013 / Accepted: 4 November 2013 / Published: 14 November 2013
    Show/Hide Abstract | Cited by 3 | PDF Full-text (570 KB) | HTML Full-text | XML Full-text

    by , , , , ,  and
    Cancers 2013, 5(4), 1485-1503; doi:10.3390/cancers5041485
    Received: 29 August 2013; in revised form: 7 October 2013 / Accepted: 1 November 2013 / Published: 8 November 2013
    Show/Hide Abstract | PDF Full-text (345 KB) | HTML Full-text | XML Full-text | Supplementary Files
    abstract graphic

    by , , ,  and
    Cancers 2013, 5(4), 1212-1220; doi:10.3390/cancers5041212
    Received: 10 July 2013; in revised form: 20 August 2013 / Accepted: 11 September 2013 / Published: 25 September 2013
    Show/Hide Abstract | PDF Full-text (344 KB) | HTML Full-text | XML Full-text

    Last update: 11 March 2013

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