Cancers 2014, 6(1), 143-152; doi:10.3390/cancers6010143
Review

The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer

1,2,* email, 1email and 1email
Received: 11 September 2013; in revised form: 1 October 2013 / Accepted: 9 January 2014 / Published: 15 January 2014
(This article belongs to the Special Issue Circulating Tumor Cells in Cancers)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Tumor cell dissemination is a common phenomenon observed in most cancers of epithelial origin. One-third of breast cancer patients present with disseminated tumor cells (DTCs) in bone marrow at time of diagnosis; these patients, as well as patients with persistent DTCs, have significantly worse clinical outcome than DTC-negative patients. Since DTC phenotype may differ from the primary tumor with regard to ER and HER2 status, reevaluation of predictive markers on DTCs may optimize treatment choices. In the present review, we report on the clinical relevance of DTC detection in breast cancer.
Keywords: breast cancer; bone marrow; disseminated tumor cell; circulating tumor cell; tumor cell dissemination
PDF Full-text Download PDF Full-Text [184 KB, uploaded 15 January 2014 09:43 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Banys, M.; Krawczyk, N.; Fehm, T. The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer. Cancers 2014, 6, 143-152.

AMA Style

Banys M, Krawczyk N, Fehm T. The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer. Cancers. 2014; 6(1):143-152.

Chicago/Turabian Style

Banys, Malgorzata; Krawczyk, Natalia; Fehm, Tanja. 2014. "The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer." Cancers 6, no. 1: 143-152.

Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert