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Cancers 2014, 6(1), 143-152; doi:10.3390/cancers6010143

The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer

1
Department of Obstetrics and Gynecology, University of Duesseldorf, Duesseldorf D-40225, Germany
2
Department of Obstetrics and Gynecology, Marienkrankenhaus Hamburg, Hamburg D-22087, Germany
*
Author to whom correspondence should be addressed.
Received: 11 September 2013 / Revised: 1 October 2013 / Accepted: 9 January 2014 / Published: 15 January 2014
(This article belongs to the Special Issue Circulating Tumor Cells in Cancers)
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Abstract

Tumor cell dissemination is a common phenomenon observed in most cancers of epithelial origin. One-third of breast cancer patients present with disseminated tumor cells (DTCs) in bone marrow at time of diagnosis; these patients, as well as patients with persistent DTCs, have significantly worse clinical outcome than DTC-negative patients. Since DTC phenotype may differ from the primary tumor with regard to ER and HER2 status, reevaluation of predictive markers on DTCs may optimize treatment choices. In the present review, we report on the clinical relevance of DTC detection in breast cancer.
Keywords: breast cancer; bone marrow; disseminated tumor cell; circulating tumor cell; tumor cell dissemination breast cancer; bone marrow; disseminated tumor cell; circulating tumor cell; tumor cell dissemination
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Banys, M.; Krawczyk, N.; Fehm, T. The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer. Cancers 2014, 6, 143-152.

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