Special Issue "Role of Oxidatively-Induced DNA Damage in Carcinogenesis"


A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (15 April 2014)

Special Issue Editor

Guest Editor
Dr. Alexandros Georgakilas
Biophysics/DNA damage and Repair Lab, Physics Department, National Technical University of Athens, Iroon Polytechneiou 9, Zografou Campus, Athens 15780, Greece
Website: http://dielectricsgroup.physics.ntua.gr/Georgakilas
E-Mail: alexg@mail.ntua.gr
Phone: +30 210 772 4453
Fax: +30 210 772 3025
Interests: radiation biology; cancer biology; DNA damage and repair; oxidative stress; carcinogenesis

Special Issue Information

Dear Colleagues,

Oxidative stress and all related effects in the cell like protein and DNA damage, mutagenesis, inactivation of DNA damage response pathways, epigenetic changes and further more importantly genomic instability and malignant transformation have gained through the years an increased attention. It is of great necessity to clarify and underline the significance and ‘real’ relevance of oxidatively-induced DNA damage in the initiation of carcinogenesis.
We would like to invite manuscripts that aim to elucidate the role(s) of oxidative stress related DNA damage of all forms in carcinogenesis and for various types of cancers like breast, brain, lung, prostate etc. We are particularly interested in manuscripts deciphering the mechanisms and pathways that oxidative DNA damage can lead to mutation and inactivation of DNA repair and apoptotic genes and epigenetic changes and new therapy tools. We are also welcome manuscripts focusing on the synergistic effects between inflammation, oxidative stress and tumorigenesis in humans and to potential anti-oxidant and anti-inflammatory pathways that reduce cancer risk. By devoting a special issue just on oxidative stress-related carcinogenesis, we hope to join forces and enhance the knowledge in the specific field and above all promote the new era of therapeutic discoveries targeting cancer through the diminution of oxidative stress and inflammation.

Dr. Alexandros Georgakilas
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 800 CHF (Swiss Francs).


  • oxidative stress
  • DNA damage
  • inflammation
  • DNA repair inactivation
  • DNA damage response
  • genomic instability
  • carcinogenesis
  • antioxidant therapies

Published Papers (4 papers)

Cancers 2014, 6(2), 771-795; doi:10.3390/cancers6020771
Received: 19 December 2013; in revised form: 20 March 2014 / Accepted: 24 March 2014 / Published: 3 April 2014
Show/Hide Abstract | Download PDF Full-text (808 KB) | Download XML Full-text

Cancers 2013, 5(4), 1332-1354; doi:10.3390/cancers5041332
Received: 16 August 2013; in revised form: 26 September 2013 / Accepted: 12 October 2013 / Published: 28 October 2013
Show/Hide Abstract | Download PDF Full-text (590 KB) | View HTML Full-text | Download XML Full-text

Cancers 2013, 5(3), 959-984; doi:10.3390/cancers5030959
Received: 3 June 2013; in revised form: 12 July 2013 / Accepted: 18 July 2013 / Published: 26 July 2013
Show/Hide Abstract | Download PDF Full-text (1096 KB) | View HTML Full-text | Download XML Full-text |  Supplementary Files

Cancers 2013, 5(3), 943-958; doi:10.3390/cancers5030943
Received: 3 May 2013; in revised form: 17 July 2013 / Accepted: 19 July 2013 / Published: 26 July 2013
Show/Hide Abstract | Download PDF Full-text (506 KB) | View HTML Full-text | Download XML Full-text

Last update: 30 October 2013

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