Supramolecular Protein Structures

Dear Colleagues,

In recent decades, the biological sciences have faced tremendous progress in the development of different analytic and genetic techniques to thoroughly identify and characterize the molecular components of different biosystems. Reductionistic approaches continue to provide biologists with deciphered genomes and tools for their manipulation, resolved structures of varied proteins, and functional parameters of biological catalysts. To use all the knowledge accumulated by the analysis, for our holistic understanding of a biosystem, particularly in determining our ability to direct its regulation, a synthesis of the current knowledge on particular cellular components is required. Understanding the principles and regulation of the homo- and hetero-oligomerization of proteins in vitro and in vivo, and the role of these processes in the formation of supramolecular structures paving the way to cellular compartmentation and metabolic regulation, represents a significant step in this synthesis.

We would like to promote this step by collecting contributions for this Special Issue from different specialists, thus supporting an interface for the exchange of methods and opinions between the related scientific fields, employing their specific approaches and backgrounds. This Special Issue intends to consider: (i) molecular mechanisms of the protein interactions with other cellular components, such as proteins, lipids, and nucleic acids; (2) multienzyme complexes and metabolomes (i.e., associates of the enzymes of a certain pathway); (3) regulatory complexes and mechanisms of their transient formation and reorganization in response to specific stimuli; (4) methodical and bioinformatics approaches to characterize the multiprotein complexes and supramolecular structures; and (5) the significance of protein interactions with other molecular components of a cell in heath and disease.

This Special Issue of Biomolecules invites your contributions on these and related topics, either in the form of original research articles or reviews.

Prof. Dr. Victoria Bunik
Guest Editor

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