Special Issue "Protein Crystallography 2016"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (30 June 2017)
We are interested in the use of radiation from the X-ray free electron laser (XFEL) for protein structure determination. An XFEL is capable of producing X-rays that are ten billion (1010) times brighter that any previous X-ray source. When one considers that protein crystallography is usually done on samples containing perhaps a trillion (1012) molecules, an intriguing question is whether the extra brightness of the XFEL will allow structure determination from individual molecules. One has to be content with signals, which are perhaps a hundred times smaller. Of course, a single molecule will scatter only diffuse intensities, devoid of Bragg spots. Finally, sample delivery systems probably will not be able to control the orientations of the samples, which should perhaps be regarded as randomly oriented.
Despite these differences with traditional protein crystallography, if structure determination is possible, it would allow structure determination of even uncrystallized proteins. This is important because there exist entire classes of proteins, e.g., membrane proteins, which are very resistant to crystallization.
Prof. Dr. Dilano K. Saldin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- membrane protein structure
- weak signals
- unknown orientations