The Molecular and Pathophysiological Basis of Ectopic Fat Deposition in Non-adipose Tissues

Dear Colleagues,

We are inviting reviews and/or original research papers for the Special Issue “The Molecular and Pathophysiological Basis of Ectopic Fat Deposition in Non-adipose tissues” for the journal

Ectopic fat deposition is a growing concern in metabolic diseases that increases the risk of morbidity and mortality. There are several types of cells affected by the intracellular accumulation of triglycerides in tissues including the liver, skeletal muscles, the heart, the pancreas, the kidneys and macrophages. The intracellular nidation and accumulation of neutral lipids interfere with the normal functions of the affected tissues. Some of the molecules involved in this process have been identified, but more studies need to be conducted on the pathways affected by the excessive accumulation of triglycerides. In addition, it is important to differentiate between the relative contribution of fasting versus feeding to lipid droplet formation and the impact of diet composition and/or physical activity to the overall accumulation of intracellular triglycerides.

This Special Issue focuses on the current state-of-the-art molecules that have been identified in the ectopic fat accumulation in tissues, with the histological and metabolic transformations that render affected tissues dysfunctional. Molecules that are potential pharmacotherapy targets are also of interest.

The manuscripts should emphasize the molecular basis of steatosis. Deadline for submission is November 2024.

Prof. Dr. Gloria Lena Vega
Prof. Dr. Amalia Gastaldelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• metabolic dysfunction-associated hepatosteatosis
• myosteatosis
• pancreatic steatosis
• pancreatic adipocytes
• visceral adipose tissue
• cardiac steatosis
• cardiac adipose tissue
• kidney steatosis
• macrophage steatosis
• perirenal adipose tissue
• lipophagy