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8.3
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Biomolecules
Special Issues
Advances in Epigenetic Regulation in Cancer
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Advances in Epigenetic Regulation in Cancer

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (25 August 2021) | Viewed by 5890

Special Issue Editor

Dr. Yuyan Han

E-Mail Website
Guest Editor
School of Biological Sciences, University of Northern Colorado, Greeley, CO 80639, USA
Interests: liver disease; cannabinoids; circadian rhythm; DNA methylation; microRNA; liver fibrosis; liver inflammation

Special Issue Information

Dear Colleagues,

Epigenetic regulation acts as a “switch” to turn on or off a gene or a chromatin region without changing the gene code. The epigenetic modification includes non-coding RNA regulation, DNA methylation, histone modification and RNA methylation. These modifications are dynamic and inheritable and can be independent from gene code. These epigenetic regulations are highly influenced by environmental factors, such as lifestyle change, exercise, therapy, stress, aging, or chemical exposure. In cancer, hypomethylation of the entire genome and hypermethylation of tumor suppressor genes are often found in various cancer types. Whole-genome DNA methylation profiling reveals signatures that can be used for predicting cancer survival or early detection. Recently, several epigenetic drugs have been used in clinical studies. Therefore, investing the role of epigenetic regulation in cancer will help us better understand the molecular mechanisms under which  environmental changes lead to tumorigenesis and progression. It has been found that the tumor tissue can be highly heterogeneous, plasticity and host a highly dynamic microenvironment. The research on epigenetic regulation will provide novel chemotherapy targets and screening methods for early detection and improved prognosis.

Dr. Yuyan Han
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Dr. Yuyan Han
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cancer
  • Epigenetic regulation
  • methylation
  • acetylation
  • non-coding RNA
  • RNA methylation
  • DNA methylation
  • histone modification
  • genetic instability
  • chromatin

Published Papers (2 papers)

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12 pages, 3023 KiB  
Article
Epigenome-Wide Association Study of Prostate Cancer in African Americans Identifies DNA Methylation Biomarkers for Aggressive Disease
by Yifan Xu, Chia-Wen Tsai, Wen-Shin Chang, Yuyan Han, Maosheng Huang, Curtis A. Pettaway, Da-Tian Bau and Jian Gu
Biomolecules 2021, 11(12), 1826; https://doi.org/10.3390/biom11121826 - 3 Dec 2021
Cited by 7 | Viewed by 2534
Abstract
DNA methylation plays important roles in prostate cancer (PCa) development and progression. African American men have higher incidence and mortality rates of PCa than other racial groups in U.S. The goal of this study was to identify differentially methylated CpG sites and genes [...] Read more.
DNA methylation plays important roles in prostate cancer (PCa) development and progression. African American men have higher incidence and mortality rates of PCa than other racial groups in U.S. The goal of this study was to identify differentially methylated CpG sites and genes between clinically defined aggressive and nonaggressive PCa in African Americans. We performed genome-wide DNA methylation profiling in leukocyte DNA from 280 African American PCa patients using Illumina MethylationEPIC array that contains about 860K CpG sties. There was a slight increase of overall methylation level (mean β value) with the increasing Gleason scores (GS = 6, GS = 7, GS ≥ 8, P for trend = 0.002). There were 78 differentially methylated CpG sites with P < 10−4 and 9 sites with P < 10−5 in the trend test. We also found 77 differentially methylated regions/genes (DMRs), including 10 homeobox genes and six zinc finger protein genes. A gene ontology (GO) molecular pathway enrichment analysis of these 77 DMRs found that the main enriched pathway was DNA-binding transcriptional factor activity. A few representative DMRs include HOXD8, SOX11, ZNF-471, and ZNF-577. Our study suggests that leukocyte DNA methylation may be valuable biomarkers for aggressive PCa and the identified differentially methylated genes provide biological insights into the modulation of immune response by aggressive PCa. Full article
(This article belongs to the Special Issue Advances in Epigenetic Regulation in Cancer)
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17 pages, 4413 KiB  
Article
Immunoprofiles and DNA Methylation of Inflammatory Marker Genes in Ulcerative Colitis-Associated Colorectal Tumorigenesis
by Satu Mäki-Nevala, Sanjeevi Ukwattage, Erkki-Ville Wirta, Maarit Ahtiainen, Ari Ristimäki, Toni T. Seppälä, Anna Lepistö, Jukka-Pekka Mecklin and Päivi Peltomäki
Biomolecules 2021, 11(10), 1440; https://doi.org/10.3390/biom11101440 - 30 Sep 2021
Cited by 3 | Viewed by 2893
Abstract
Immunological and epigenetic changes are interconnected and contribute to tumorigenesis. We determined the immunoprofiles and promoter methylation of inflammation-related genes for colitis-associated colorectal carcinomas (CA-CRC). The results were compared with Lynch syndrome (LS)-associated colorectal tumors, which are characterized by an active immune environment [...] Read more.
Immunological and epigenetic changes are interconnected and contribute to tumorigenesis. We determined the immunoprofiles and promoter methylation of inflammation-related genes for colitis-associated colorectal carcinomas (CA-CRC). The results were compared with Lynch syndrome (LS)-associated colorectal tumors, which are characterized by an active immune environment through inherited mismatch repair defects. CA-CRCs (n = 31) were immunohistochemically evaluated for immune cell scores (ICSs) and PDCD1 and CD274 expression. Seven inflammation-associated genes (CD274, NTSR1, PPARG, PTGS2, PYCARD, SOCS1, and SOCS2), the repair gene MGMT, and eight standard marker genes for the CpG Island Methylator Phenotype (CIMP) were investigated for promoter methylation in CA-CRCs, LS tumors (n = 29), and paired normal mucosae by multiplex ligation-dependent probe amplification. All but one CA-CRCs were microsatellite-stable and all LS tumors were microsatellite-unstable. Most CA-CRCs had a high ICS (55%) and a positive CD274 expression in immune cells (52%). NTSR1 revealed frequent tumor-specific hypermethylation in CA-CRC and LS. When compared to LS mucosae, normal mucosae from patients with CA-CRC showed significantly higher methylation of NTSR1 and most CIMP markers. In conclusion, CA-CRCs share a frequent ICShigh/CD274pos expression pattern with LS tumors. Elevated methylation in normal mucosa may indicate field cancerization as a feature of CA-CRC-associated tumorigenesis. Full article
(This article belongs to the Special Issue Advances in Epigenetic Regulation in Cancer)
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