Special Issue "Antimicrobial Peptides: Development, Conjugation, and Beyond"

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: 28 February 2018

Special Issue Editor

Guest Editor
Prof. Dr. Suzana K. Straus

Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
Website | E-Mail
Interests: antimicrobial peptides; bioconjugation; mechanism of action; structural biology; biophysical chemistry; nuclear magnetic resonance; lipid-protein interactions; protein–protein interactions; membrane-associated peptides and proteins

Special Issue Information

Dear Colleagues,

Bacterial resistance means that many researchers are looking for alternatives to currently-used antibiotics. One strategy being explored is to use antimicrobial peptides (AMPs). AMPs are considered to be viable alternatives to currently-used antibiotics, because they have a broad antimicrobial spectrum and since bacteria develop little or no resistance towards them. In addition, AMPs are ubiquitous in nature and are involved in the first line of defense in plants and animals.

Although AMPs are promising, only a few are used for systemic therapy. The number of AMPs currently being used is limited because these compounds often display adverse effects such as unknown toxicity against host cells, short circulation half-life due to protease digestion and rapid kidney clearance. To circumvent these issues, a number of strategies are being explored to improve the properties of AMPs via formulations and conjugation to biocompatible polymers. Solutions to the limitation of enzymatic degradation have been investigated by the incorporation of d-amino acids, chemical modification of the peptide (side chain groups, N and C-termini,) cyclization, as well as polymer conjugation. This Special Issue will explore recent advancements in AMP research, as well as the methods to minimize their limitations.

Prof. Dr. Suzana K. Straus
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • antimicrobial peptides (AMPs)
  • biophysical characterization
  • mode of action
  • bioconjugation of AMPs
  • limitation of enzymatic degradation
  • d-amino acids use in AMPs
  • cyclization of AMPs
  • chemical modification of AMPs

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Modulation of the Antimicrobial Activity of Tritrpticin by Changing the Length of Cationic Residues
Authors: Mauricio Arias, Kathlyn Piga and Hans J. Vogel

Title: Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo
Authors: Prashant Kumar, Jayachandran N. Kizhakkedathu and Suzana K. Straus

Title: Biophysical Investigations Elucidating the Mechanisms of Action of Antimicrobial Peptides and their Synergism
Authors: Burkhard Bechinger

Title: Chimeric Human Antimicrobial Peptide Tethering and Bioactivity on Collagen-Alginate Composite Dressings
Authors: Lindsay D. Lozeau, Ramona B. Bago, Mateo F. Frare, Terri A. Camesano and Marsha W. Rolle

Title: Antibiofilm peptide mimics
Authors: Natalia Molchanova, Athina Andrea and Håvard Jenssen

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