Special Issue "Gene Expression and Regulation"
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (31 October 2012)
Dr. Mary O'Connell (Website)
Medical Research Council, Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
Interests: RNA editing; RNA Protein interaction; RNA interference
Gene expression and how it is regulated is a fundamental question in biology and therefore its complexity is not surprising. Initially the major focus of research was on transcription factors as the major modulators of gene expression. Then enhancers and enhancer binding proteins were found to be critical for gene expression. In recent years epigenetic changes such as DNA methylation and histone methylation have added layers of complexity as they also regulate gene expression. Long range DNA looping can also influence gene expression as it brings promoters and enhancers proximal to genes. With the availability of high throughput sequencing profiling of gene expression in different tissues and also in different diseases has become a very active area of research. What has become a major challenge is to draw a coherent picture from a large volume of data, of what are key regulators of gene expression. This special issue will cover original research papers on this very broad topic. The submission of reviews is also welcomed.
Dr. Mary O'Connell
- transcription factors
- enhancer binding proteins
- DNA methylation
- histone methylation
- DNA looping
- expression profiling
- miRNA and post-translational gene silencing
- asymmetrical distribution of genetic factors