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Biology 2013, 2(3), 976-1033; doi:10.3390/biology2030976

The Role of Nuclear Bodies in Gene Expression and Disease

Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
Author to whom correspondence should be addressed.
Received: 15 May 2013 / Revised: 13 June 2013 / Accepted: 20 June 2013 / Published: 9 July 2013
(This article belongs to the Special Issue Gene Expression and Regulation)
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This review summarizes the current understanding of the role of nuclear bodies in regulating gene expression. The compartmentalization of cellular processes, such as ribosome biogenesis, RNA processing, cellular response to stress, transcription, modification and assembly of spliceosomal snRNPs, histone gene synthesis and nuclear RNA retention, has significant implications for gene regulation. These functional nuclear domains include the nucleolus, nuclear speckle, nuclear stress body, transcription factory, Cajal body, Gemini of Cajal body, histone locus body and paraspeckle. We herein review the roles of nuclear bodies in regulating gene expression and their relation to human health and disease.
Keywords: nuclear bodies; transcription; gene expression; genome organization nuclear bodies; transcription; gene expression; genome organization

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Morimoto, M.; Boerkoel, C.F. The Role of Nuclear Bodies in Gene Expression and Disease. Biology 2013, 2, 976-1033.

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