Biology 2013, 2(1), 26-39; doi:10.3390/biology2010026
Review

Gene Expression and Regulation in Adrenocortical Tumorigenesis

1,2,* email, 1,2email, 1,2email, 2email and 1,2email
Received: 31 October 2012; in revised form: 1 December 2012 / Accepted: 14 December 2012 / Published: 27 December 2012
(This article belongs to the Special Issue Gene Expression and Regulation)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Adrenocortical tumors are frequently found in the general population, and may be benign adrenocortical adenomas or malignant adrenocortical carcinomas. Unfortunately the clinical, biochemical and histopathological distinction between benign and malignant adrenocortical tumors may be difficult in the absence of widely invasive or metastatic disease, and hence attention has turned towards a search for molecular markers. The study of rare genetic diseases that are associated with the development of adrenocortical carcinomas has contributed to our understanding of adrenocortical tumorigenesis. In addition, comprehensive genomic hybridization, methylation profiling, and genome wide mRNA and miRNA profiling have led to improvements in our understanding, as well as demonstrated several genes and pathways that may serve as diagnostic or prognostic markers.
Keywords: adrenocortical tumor; epigenetics; gene expression; genetics
PDF Full-text Download PDF Full-Text [170 KB, uploaded 27 December 2012 16:30 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Fonseca, A.L.; Healy, J.; Kunstman, J.W.; Korah, R.; Carling, T. Gene Expression and Regulation in Adrenocortical Tumorigenesis. Biology 2013, 2, 26-39.

AMA Style

Fonseca AL, Healy J, Kunstman JW, Korah R, Carling T. Gene Expression and Regulation in Adrenocortical Tumorigenesis. Biology. 2013; 2(1):26-39.

Chicago/Turabian Style

Fonseca, Annabelle L.; Healy, James; Kunstman, John W.; Korah, Reju; Carling, Tobias. 2013. "Gene Expression and Regulation in Adrenocortical Tumorigenesis." Biology 2, no. 1: 26-39.


Biology EISSN 2079-7737 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert