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Gene Expression and Regulation in Adrenocortical Tumorigenesis
Department of Surgery, Yale Endocrine Neoplasia Laboratory, Yale University School of Medicine, 333 Cedar Street, TMP202 Box 208062, New Haven, CT 06520, USA
Yale Endocrine Neoplasia Laboratory, Yale University School of Medicine, New Haven, CT 06520, USA
* Author to whom correspondence should be addressed.
Received: 31 October 2012; in revised form: 1 December 2012 / Accepted: 14 December 2012 / Published: 27 December 2012
Abstract: Adrenocortical tumors are frequently found in the general population, and may be benign adrenocortical adenomas or malignant adrenocortical carcinomas. Unfortunately the clinical, biochemical and histopathological distinction between benign and malignant adrenocortical tumors may be difficult in the absence of widely invasive or metastatic disease, and hence attention has turned towards a search for molecular markers. The study of rare genetic diseases that are associated with the development of adrenocortical carcinomas has contributed to our understanding of adrenocortical tumorigenesis. In addition, comprehensive genomic hybridization, methylation profiling, and genome wide mRNA and miRNA profiling have led to improvements in our understanding, as well as demonstrated several genes and pathways that may serve as diagnostic or prognostic markers.
Keywords: adrenocortical tumor; epigenetics; gene expression; genetics
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MDPI and ACS Style
Fonseca, A.L.; Healy, J.; Kunstman, J.W.; Korah, R.; Carling, T. Gene Expression and Regulation in Adrenocortical Tumorigenesis. Biology 2013, 2, 26-39.
Fonseca AL, Healy J, Kunstman JW, Korah R, Carling T. Gene Expression and Regulation in Adrenocortical Tumorigenesis. Biology. 2013; 2(1):26-39.
Fonseca, Annabelle L.; Healy, James; Kunstman, John W.; Korah, Reju; Carling, Tobias. 2013. "Gene Expression and Regulation in Adrenocortical Tumorigenesis." Biology 2, no. 1: 26-39.