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Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription
Department of Biochemistry and Molecular Biology, College of Medicine, Genetics Institute, University of Florida, 1600 SW Archer Road, Gainesville, FL, 32610, USA
Institute of Molecular Oncology, BSRC Alexander Fleming, Varkiza, 16002, Greece
* Author to whom correspondence should be addressed.
Received: 1 November 2012; in revised form: 21 November 2012 / Accepted: 21 November 2012 / Published: 5 December 2012
Abstract: Enhancer elements regulate the tissue- and developmental-stage-specific expression of genes. Recent estimates suggest that there are more than 50,000 enhancers in mammalian cells. At least a subset of enhancers has been shown to recruit RNA polymerase II transcription complexes and to generate enhancer transcripts. Here, we provide an overview of enhancer function and discuss how transcription of enhancers or enhancer-generated transcripts could contribute to the regulation of gene expression during development and differentiation.
Keywords: gene regulation; chromatin; transcription factor; noncoding RNA; histone modifications; enhancer; promoter
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Stees, J.S.; Varn, F.; Huang, S.; Strouboulis, J.; Bungert, J. Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription. Biology 2012, 1, 778-793.
Stees JS, Varn F, Huang S, Strouboulis J, Bungert J. Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription. Biology. 2012; 1(3):778-793.
Stees, Jared S.; Varn, Fred; Huang, Suming; Strouboulis, John; Bungert, Jörg. 2012. "Recruitment of Transcription Complexes to Enhancers and the Role of Enhancer Transcription." Biology 1, no. 3: 778-793.