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Applied Sciences
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Microfabrication and Patterning Techniques in Tissue Engineering and Regenerative Medicine
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Microfabrication and Patterning Techniques in Tissue Engineering and Regenerative Medicine

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: closed (28 February 2019) | Viewed by 10719

Special Issue Editors

Dr. Maurice N. Collins

E-Mail Website
Guest Editor
Stokes Laboratories, Bernal institute, University of Limerick, Limerick, Ireland
Interests: structure/property relationships in polymers; biopolymers; biomedical polymers; tissue engineering; polymer composites; polymer processing; hydrogels
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Joaquim Miguel Oliveira

E-Mail Website
Co-Guest Editor
3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR-Portugal; ICVS/3B’s - PT Government Associated Laboratory, Portugal
Interests: nanobiomaterials; nanomedicine; theranostics; tissue engineering; 3D printing; 3D in vitro tissue models of disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfabrication and patterning techniques are gaining ever more importance. 3D bioprinting shows great deal of promise to revolutionize the field of tissue engineering and regenerative medicine, due to its ability to generate mimetic tissues and organs on demand. This can only be realized by advancing bioink development in order to produce patient-specific scaffolds with inbuilt hierarchical structures and memory-shape properties, while offering enhanced biological properties. It is expected that this will allow the realization of the bioinspired design approach. Further to this, 3D patterning of scaffolding materials is possible using spatially controlled light exposure and capillary force lithography on biological films and scaffolds to tune mechanical and degradation properties. For example, femtosecond laser induced two-photon polymerization is capable of producing 3D nanoscale patterns on hydrogel scaffolds with precise control of geometry. Protein structures can be patterned within these 3D hydrogels with nanoscale resolution to allow the incorporated chemical cues associated with the extracellular matrix (ECM). This Special Issue of the journal Applied Sciences is focused on “Microfabrication and Patterning Techniques in Tissue Engineering and Regenerative Medicine” aims to cover the latest research findings and recent advances in the field.

Dr. Maurice N. Collins
Prof. Dr. J. Miguel Oliveira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D Printing
  • Biomaterials
  • Biopolymers
  • Bioinks
  • Hydrogels
  • Microfabrication
  • Musculoskeletal
  • Patterning
  • Processing methods
  • Tissue engineering and regenerative medicine

Published Papers (2 papers)

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Research

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14 pages, 3709 KiB  
Article
Fabrication of Oxygen Releasing Scaffold by Embedding H2O2-PLGA Microspheres into Alginate-Based Hydrogel Sponge and Its Application for Wound Healing
by Jeongyeon Choi, Gyeongsik Hong, Taegyun Kwon and Jeong Ok Lim
Appl. Sci. 2018, 8(9), 1492; https://doi.org/10.3390/app8091492 - 29 Aug 2018
Cited by 32 | Viewed by 5844
Abstract
In the regeneration process for new tissues, oxygen promotes re-epithelialization and healing of infected wounds, increases keratinocyte differentiation, proliferation and migration of fibroblast, and induces angiogenesis, collagen synthesis and wound contraction. Therefore, provision of oxygen to cells and tissues at an optimal level [...] Read more.
In the regeneration process for new tissues, oxygen promotes re-epithelialization and healing of infected wounds, increases keratinocyte differentiation, proliferation and migration of fibroblast, and induces angiogenesis, collagen synthesis and wound contraction. Therefore, provision of oxygen to cells and tissues at an optimal level is critical for effective tissue regeneration and wound healing. In this study, we developed sustained oxygen-releasing polymeric microspheres and fabricated a sponge type dressing by embedding the microspheres into alginate-based hydrogel that can supply oxygen to wounds. We further investigated the applicability of the microspheres and hydrogel sponge to wound healing in vitro and in vivo. Oxygen-releasing microspheres (ORM) were made by incorporating hydrogen peroxide (H2O2) into poly(lactic-co-glycolic acid) (PLGA) using double emulsion method. H2O2-PLGA microspheres were embedded into alginate-based hydrogel to form a porous oxygen-releasing hydrogel sponge (ORHS). Biocompatibility was performed using cell counting kit-8. The oxygen release kinetic study was performed using a hydrogen peroxide assay kit and oxygen meter. The wound healing potential of ORHS was evaluated using the wound scratch model. In vivo studies were carried out to investigate the safety and efficacy of the ORHS for wound healing. Experimental results confirmed that oxygen released from ORMand ORHS induced neovascularization and promoted cell proliferation thereby facilitating effective wound healing. It is suggested that the ORM can be used for supplying oxygen to where cells and tissues are deprived of necessary oxygen, and ORHS is an intelligent scaffold to effectively heal wound by enhanced angiogenesis by oxygen. Conclusively, oxygen releasing polymeric microspheres and hydrogel scaffolds have potential for a variety of tissue engineering applications, where require oxygen. Full article
(This article belongs to the Special Issue Microfabrication and Patterning Techniques in Tissue Engineering and Regenerative Medicine)
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Review

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16 pages, 251 KiB  
Review
3D Printing Applied to Tissue Engineered Vascular Grafts
by Raphaël Wenger and Marie-Noëlle Giraud
Appl. Sci. 2018, 8(12), 2631; https://doi.org/10.3390/app8122631 - 15 Dec 2018
Cited by 30 | Viewed by 4384
Abstract
The broad clinical use of synthetic vascular grafts for vascular diseases is limited by their thrombogenicity and low patency rate, especially for vessels with a diameter inferior to 6 mm. Alternatives such as tissue-engineered vascular grafts (TEVGs), have gained increasing interest. Among the [...] Read more.
The broad clinical use of synthetic vascular grafts for vascular diseases is limited by their thrombogenicity and low patency rate, especially for vessels with a diameter inferior to 6 mm. Alternatives such as tissue-engineered vascular grafts (TEVGs), have gained increasing interest. Among the different manufacturing approaches, 3D bioprinting presents numerous advantages and enables the fabrication of multi-scale, multi-material, and multicellular tissues with heterogeneous and functional intrinsic structures. Extrusion-, inkjet- and light-based 3D printing techniques have been used for the fabrication of TEVG out of hydrogels, cells, and/or solid polymers. This review discusses the state-of-the-art research on the use of 3D printing for TEVG with a focus on the biomaterials and deposition methods. Full article
(This article belongs to the Special Issue Microfabrication and Patterning Techniques in Tissue Engineering and Regenerative Medicine)
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