Special Issue "Tissue Engineering and Regenerative Nanomedicine"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 31 March 2018

Special Issue Editors

Guest Editor
Prof. Dr. Joaquim Miguel Oliveira

3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR-Portugal; ICVS/3B’s - PT Government Associated Laboratory, Portugal
Website | E-Mail
Interests: nanobiomaterials; nanomedicine; theranostics; tissue engineering; and 3D in vitro tissue models of disease
Guest Editor
Prof. Dr. Rui L. Reis

3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR-Portugal; ICVS/3B’s - PT Government Associated Laboratory, Portugal
Website | E-Mail
Interests: materials science; stem cells; tissue engineering; regenerative medicine

Special Issue Information

Dear Colleagues,

The convergence of the regenerative principles in Nanomedicine and Tissue Engineering promise to create new avenues in Regenerative Medicine. It is now recognized the great advantages of using nanomaterials for controlled drug delivery, scaffolding, sensing and imaging applications. Emerging engineering strategies possibly synthesizing nanosystems with different compositions and architectures. Multi-modal nanomaterials are now being designed by means of incorporating different stimuli-responsive functionalities, peptides, antibodies and imaging probes towards targeting specific cells, tissues and organs while offering the possibility to track its fate in real-time.

This Special Issue focus on the most recent advances related to the design of different nanobiomaterials, functionalization strategies, processing methods, biological performance assessment and safety, and its applications for theranostics of cancer, musculoskeletal and neurodegenerative diseases/disorders.

Submissions can cover the following topics (but are not limited to them):

·         Design, synthesis and functionalization of nanobiomaterials

·         Formulation and processing of nanomaterials

·         Strategies combining nanoparticles and emerging technologies (e.g. microfluidics)

·         Pre-clinical characterization of nanomaterials

·         Nanoparticles for imaging and diagnosis

·         Applications of nanomaterials in theranostics of cancer, musculoskeletal and neurodegenerative diseases/disorders.

Prof. Dr. Joaquim Miguel  Oliveira
Prof. Dr. Rui L.  Reis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

 ·    Cancer
 ·    Imaging
 ·    Musculoskeletal
 ·    Nanobiomaterials
 ·    Neurosciences
 ·    Processing methods
 ·    Nanomedicine
 ·    Tissue engineering

Published Papers (2 papers)

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Research

Open AccessArticle Porcine Dental Epithelial Cells Differentiated in a Cell Sheet Constructed by Magnetic Nanotechnology
Nanomaterials 2017, 7(10), 322; doi:10.3390/nano7100322
Received: 14 September 2017 / Revised: 7 October 2017 / Accepted: 9 October 2017 / Published: 13 October 2017
PDF Full-text (7921 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Magnetic nanoparticles (MNPs) are widely used in medical examinations, treatments, and basic research, including magnetic resonance imaging, drug delivery systems, and tissue engineering. In this study, MNPs with magnetic force were applied to tissue engineering for dental enamel regeneration. The internalization of MNPs
[...] Read more.
Magnetic nanoparticles (MNPs) are widely used in medical examinations, treatments, and basic research, including magnetic resonance imaging, drug delivery systems, and tissue engineering. In this study, MNPs with magnetic force were applied to tissue engineering for dental enamel regeneration. The internalization of MNPs into the odontogenic cells was observed by transmission electron microscopy. A combined cell sheet consisting of dental epithelial cells (DECs) and dental mesenchymal cells (DMCs) (CC sheet) was constructed using magnetic force-based tissue engineering technology. The result of the iron staining indicated that MNPs were distributed ubiquitously over the CC sheet. mRNA expression of enamel differentiation and basement membrane markers was examined in the CC sheet. Immunostaining showed Collagen IV expression at the border region between DEC and DMC layers in the CC sheet. These results revealed that epithelial–mesenchymal interactions between DEC and DMC layers were caused by bringing DECs close to DMCs mechanically by magnetic force. Our study suggests that the microenvironment in the CC sheet might be similar to that during the developmental stage of a tooth bud. In conclusion, a CC sheet employing MNPs could be developed as a novel and unique graft for artificially regenerating dental enamel. Full article
(This article belongs to the Special Issue Tissue Engineering and Regenerative Nanomedicine)
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Open AccessArticle The Bioactivity and Photocatalytic Properties of Titania Nanotube Coatings Produced with the Use of the Low-Potential Anodization of Ti6Al4V Alloy Surface
Nanomaterials 2017, 7(8), 197; doi:10.3390/nano7080197
Received: 6 July 2017 / Revised: 21 July 2017 / Accepted: 21 July 2017 / Published: 26 July 2017
Cited by 1 | PDF Full-text (10000 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Titania nanotube (TNT) coatings were produced using low-potential anodic oxidation of Ti6Al4V substrates in the potential range 3–20 V. They were analysed by X-ray diffraction (XRD), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). The wettability was estimated by measuring
[...] Read more.
Titania nanotube (TNT) coatings were produced using low-potential anodic oxidation of Ti6Al4V substrates in the potential range 3–20 V. They were analysed by X-ray diffraction (XRD), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). The wettability was estimated by measuring the contact angle when applying water droplets. The bioactivity of the TNT coatings was established on the basis of the biointegration assay (L929 murine fibroblasts adhesion and proliferation) and antibacterial tests against Staphylococcus aureus (ATCC 29213). The photocatalytic efficiency of the TNT films was studied by the degradation of methylene blue under UV irradiation. Among the studied coatings, the TiO2 nanotubes obtained with the use of 5 V potential (TNT5) were found to be the most appropriate for medical applications. The TNT5 sample possessed antibiofilm properties without enriching it by additional antimicrobial agent. Furthermore, it was characterized by optimal biocompatibility, performing better than pure Ti6Al4V alloy. Moreover, the same sample was the most photocatalytically active and exhibited the potential for the sterilization of implants with the use of UV light and for other environmental applications. Full article
(This article belongs to the Special Issue Tissue Engineering and Regenerative Nanomedicine)
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