Special Issue "Efflux Pumps of Multi-Drug Resistant Pathogenic Bacteria: Their Genetic Regulation, Molecular Biology and Possible Control with Newly Designed Agents"
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (31 December 2012)
Prof. Dr. Leonard Amaral
Institute of Hygiene & Tropical Medicine, Rua Junqueira 100, 1349-008 Lisbon, Portugal
Interests: antibiotic resistance; multi-drug resistance; bacterial infections; efflux pumps; reversal of resistance; MDR/XDR Tb; therapy; molecular genetics; molecular biology; drug discovery
Multi-drug resistance of pathogenic bacterial clinical isolates is now known to be mainly due to over-expressed efflux pumps that result from therapy with antibiotics that is either ineffective or improperly administered . The development of the MDR phenotype is thus problematic to therapy since resistance to the antibiotic initially used also bestows resistance to antibiotics of the same class and or other classes of antibiotics [1,2]. For the past two decades, much has been learned about the regulation and control of efflux pumps that render the clinical isolate with an MDR phenotype. Nevertheless, at this time, although many compounds have been identified to affect the activity of the over-expressed efflux pump of a given MDR bacterium and therefore render the antibiotic bacterium susceptible to antibiotics to which it was initially resistant, none have yet to reach the market as adjuncts to antibiotic therapy. The special issue of “Antibiotics” "Efflux pumps of multi-drug resistant pathogenic bacteria: Their genetic regulation, molecular biology and possible control with newly designed agents." will receive contributions from experts in the field of efflux pumps, their regulation and potential control with newly discovered agents from natural and chemically derived sources. We hope that those who are conducting research in this area will also submit their contributions for publication in this special issue.
1. Amaral, L.; Fanning, S.; Pagès, J.M. Efflux pumps of gram-negative bacteria: Genetic responses to stress and the modulation of their activity by pH, inhibitors, and phenothiazines. Adv. Enzymol. Relat. Areas Mol. Biol. 2011, 77, 61–108. Review.
2. Pagès, J.M.; Amaral, L. Fanning, S. An original deal for new molecule: Reversal of efflux pump activity, a rational strategy to combat Gram-negative resistant bacteria. Curr. Med. Chem. 2011, 18, 2969–2680.
Prof. Dr. Leonard Amaral
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
Antibiotics 2012, 1(1), 29-43; doi:10.3390/antibiotics1010029
Received: 29 October 2012; in revised form: 16 November 2012 / Accepted: 16 November 2012 / Published: 21 November 2012| Download PDF Full-text (509 KB) | Download XML Full-text
Article: The Staphylococcus aureus Membrane Protein SA2056 Interacts with Peptidoglycan Synthesis Enzymes
Antibiotics 2013, 2(1), 11-27; doi:10.3390/antibiotics2010011
Received: 24 December 2012; in revised form: 16 January 2013 / Accepted: 16 January 2013 / Published: 22 January 2013| Download PDF Full-text (669 KB) | Download XML Full-text | Supplementary Files
Review: Recent Advances in Multi-Drug Resistance (MDR) Efflux Pump Inhibitors of Gram-Positive Bacteria S. aureus
Antibiotics 2013, 2(1), 28-45; doi:10.3390/antibiotics2010028
Received: 4 January 2013; in revised form: 29 January 2013 / Accepted: 30 January 2013 / Published: 5 February 2013| Download PDF Full-text (464 KB) | Download XML Full-text
Review: Role of Phenothiazines and Structurally Similar Compounds of Plant Origin in the Fight against Infections by Drug Resistant Bacteria
Antibiotics 2013, 2(1), 58-72; doi:10.3390/antibiotics2010058
Received: 26 December 2012; in revised form: 28 January 2013 / Accepted: 31 January 2013 / Published: 18 February 2013| Download PDF Full-text (358 KB)
Article: Virulence of Acinetobacter baumannii Exhibiting Phenotypic Heterogeneous Growth against Meropenem in a Murine Thigh Infection Model
Antibiotics 2013, 2(1), 73-82; doi:10.3390/antibiotics2010073
Received: 14 January 2013; in revised form: 16 February 2013 / Accepted: 1 March 2013 / Published: 11 March 2013| Download PDF Full-text (330 KB) | Download XML Full-text
Antibiotics 2013, 2(1), 83-99; doi:10.3390/antibiotics2010083
Received: 15 January 2013; in revised form: 4 March 2013 / Accepted: 5 March 2013 / Published: 13 March 2013| Download PDF Full-text (575 KB) | Download XML Full-text | Supplementary Files
Review: Resistance-Nodulation-Division Multidrug Efflux Pumps in Gram-Negative Bacteria: Role in Virulence
Antibiotics 2013, 2(1), 163-181; doi:10.3390/antibiotics2010163
Received: 28 December 2012; in revised form: 5 March 2013 / Accepted: 11 March 2013 / Published: 18 March 2013| Download PDF Full-text (377 KB) | Download XML Full-text
Antibiotics 2013, 2(2), 182-190; doi:10.3390/antibiotics2020182
Received: 14 January 2013; in revised form: 18 March 2013 / Accepted: 22 March 2013 / Published: 27 March 2013| Download PDF Full-text (444 KB) | Download XML Full-text
Last update: 25 September 2012