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Antibiotics 2013, 2(1), 83-99; doi:10.3390/antibiotics2010083
Article

Resistance to Antimicrobials Mediated by Efflux Pumps in Staphylococcus aureus

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Received: 15 January 2013; in revised form: 4 March 2013 / Accepted: 5 March 2013 / Published: 13 March 2013
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Abstract: Resistance mediated by efflux has been recognized in Staphylococcus aureus in the last few decades, although its clinical relevance has only been recognized recently. The existence of only a few studies on the individual and overall contribution of efflux to resistance phenotypes associated with the need of well-established methods to assess efflux activity in clinical isolates contributes greatly to the lack of solid knowledge of this mechanism in S. aureus. This study aims to provide information on approaches useful to the assessment and characterization of efflux activity, as well as contributing to our understanding of the role of efflux to phenotypes of antibiotic resistance and biocide tolerance in S. aureus clinical isolates. The results described show that efflux is an important contributor to fluoroquinolone resistance in S. aureus and suggest it as a major mechanism in the early stages of resistance development. We also show that efflux plays an important role on the reduced susceptibility to biocides in S. aureus, strengthening the importance of this long neglected resistance mechanism to the persistence and proliferation of antibiotic/biocide-resistant S. aureus in the hospital environment.
Keywords: Staphylococcus aureus; resistance; antibiotics; biocides; efflux Staphylococcus aureus; resistance; antibiotics; biocides; efflux
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Costa, S.S.; Junqueira, E.; Palma, C.; Viveiros, M.; Melo-Cristino, J.; Amaral, L.; Couto, I. Resistance to Antimicrobials Mediated by Efflux Pumps in Staphylococcus aureus. Antibiotics 2013, 2, 83-99.

AMA Style

Costa SS, Junqueira E, Palma C, Viveiros M, Melo-Cristino J, Amaral L, Couto I. Resistance to Antimicrobials Mediated by Efflux Pumps in Staphylococcus aureus. Antibiotics. 2013; 2(1):83-99.

Chicago/Turabian Style

Costa, Sofia S.; Junqueira, Elisabete; Palma, Cláudia; Viveiros, Miguel; Melo-Cristino, José; Amaral, Leonard; Couto, Isabel. 2013. "Resistance to Antimicrobials Mediated by Efflux Pumps in Staphylococcus aureus." Antibiotics 2, no. 1: 83-99.


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