Signaling Molecules in Mammalian Reproduction

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Reproduction".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 4259

Special Issue Editors


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Guest Editor
Department of Reproduction, Obstetrics and Herd Health, Ghent University, 9820 Merelbeke, Belgium
Interests: animal reproduction; extracellular vesicles; epigenetics; miRNAs

E-Mail Website
Guest Editor
Head of Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium
Interests: embryo; gametes; cryopreservation; assisted reproduction epigenetics; miRNAs; extracellular vesicles; micromanipulation

Special Issue Information

Dear Colleagues,

Efficient communication between cells and tissues is necessary for many physiological processes, including embryo development. Typically, inside the body, mammalian cells communicate with each other either through direct interaction (juxtacrine signalling) or by secreting molecules such as hormones, growth factors, and cytokines. Mammalian preimplantation embryos develop in vivo inside the female genital tract (i.e., the oviduct and uterus) and communicate with these dynamic and elastic surroundings on which the embryo depends for its development and survival. However, cell–cell communication is changed completely when cells are cultured outside the body, in vitro. Recent decades have seen a growing interest in the study of miRNAs, extracellular vesicles, proteins, and other signalling molecules driven by their role in cellular communication, and potential as biomarkers.

The scope of this Special Issue includes reviews and original research papers focused on identifying or characterizing different signalling factors that are involved in mammalian reproduction both in vivo and in vitro. However, articles related to the use of animals solely to provide information of relevance to humans are not suitable for this Special Issue.

Dr. Krishna C. Pavani
Prof. Dr. Ann Van Soom
Guest Editors

Manuscript Submission Information

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Keywords

  • miRNAs
  • Extracellular vesicles
  • mRNAs
  • Proteins
  • Lipids
  • Antioxidants

Published Papers (1 paper)

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Research

17 pages, 17791 KiB  
Article
Identification and Characterization of lncRNA and mRNA in Testes of Landrace and Hezuo Boars
by Bo Zhang, Zunqiang Yan, Pengfei Wang, Qiaoli Yang, Xiaoyu Huang, Haixia Shi, Yuran Tang, Yanan Ji, Juanli Zhang and Shuangbao Gun
Animals 2021, 11(8), 2263; https://doi.org/10.3390/ani11082263 - 30 Jul 2021
Cited by 9 | Viewed by 2643
Abstract
Chinese HZ boars are typical plateau miniature boars characterized by precocious puberty, which is closely related to testicular development and spermatogenesis. Accumulating evidence indicates that lncRNA is involved in the testicular development and regulation of spermatogenesis. However, little is known about the lncRNA [...] Read more.
Chinese HZ boars are typical plateau miniature boars characterized by precocious puberty, which is closely related to testicular development and spermatogenesis. Accumulating evidence indicates that lncRNA is involved in the testicular development and regulation of spermatogenesis. However, little is known about the lncRNA precocious regulation in testicular development and spermatogenesis on early sexual maturity of HZ boars. Thus, we investigated the expression and characterization of lncRNA and mRNA in 30-day-old and 120-day-old HZ boar testes using transcriptome to explore precocious puberty. Landrace (LC) boar was treated as the control. Histological analyses indicated that HZ boar underwent puberty development at an earlier stage than LC boar and had achieved sexual maturity at 120 days old. RNA-Seq yielded a total of 187 lncRNAs and 984 mRNAs; these molecules were identified as possible candidates for precocious puberty. GO terms and KEGG pathways enrichment analyses revealed that the differentially expressed lncRNA and their targeted genes were involved in metabolic pathways regulating testis development and spermatogenesis, such as the PI3K-Akt, TGF-beta and Wnt pathways. Further screening, some lncRNA (such as LOC102166140, LOC110259451, and MSTRG.15011.2), and mRNA (such as PDCL2, HSD17B4, SHCBP1L, CYP21A2, and SPATA3) were found to be possibly associated with precocious puberty, which would add to our understanding of the molecular regulatory mechanisms of precocious puberty. This study provided valuable information for further study of the role of lncRNA and mRNA in the process of precocious puberty. Full article
(This article belongs to the Special Issue Signaling Molecules in Mammalian Reproduction)
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